PMID- 17068105
OWN - NLM
STAT- MEDLINE
DCOM- 20070122
LR  - 20171116
IS  - 0953-8178 (Print)
IS  - 0953-8178 (Linking)
VI  - 18
IP  - 12
DP  - 2006 Dec
TI  - Distinctive role of donor strain immature dendritic cells in the creation of 
      allograft tolerance.
PG  - 1771-7
AB  - Dendritic cells (DCs) are pivotal antigen-presenting cells and serve a unique 
      role in initiating immunity. To test the hypothesis that pre-immunization of 
      recipient with certain DC subsets of donor origin can influence graft outcome, we 
      have studied the effects of immunization with allogeneic CD4(+)CD8(-)CD11c(+) 
      dendritic cell (CD4(+)DC) and CD4(-)CD8(+)CD11c(+) dendritic cell (CD8(+)DC) on 
      the allograft response. Although both immature CD4(+)DC and CD8(+)DC subsets from 
      DBA/2 were able to prime naive allogeneic C57BL/6 (B6) T cells in mixed 
      lymphocyte reaction (MLR), CD8(+)DC exerted more vigorous alloimmune responses 
      than CD4(+)DC did. Also, CD4(+)DC-driven allogeneic T cell response was 
      attenuated more significantly by anti-CD154 mAb than CD8(+)DC-driven response. 
      Consistent with the MLR results, combined pre-treatment with CD4(+)DC, but not 
      CD8(+)DC, plus anti-CD154 mAb produced donor strain-specific long-term graft 
      survival and induced tolerance while treatment with CD8(+)DC plus anti-CD154 mAb 
      created minimal prolongation of allograft survival in a pancreas islet transplant 
      model (DBA/2-->B6). The beneficial effects exerted by CD4(+)DC and anti-CD154 mAb 
      pre-treatment were correlated with T(h)1 to T(h)2 immune deviation and with the 
      amplified donor-specific suppressive capacity by recipient CD4(+)CD25(+) T cells. 
      These findings highlight the capacity of CD4(+)DC to modulate alloimmune 
      responses, and suggest therapeutic approaches for the induction of donor-specific 
      tolerance.
FAU - Kim, Yon Su
AU  - Kim YS
AD  - Department of Internal Medicine, Seoul National University College of Medicine, 
      Seoul, Korea. yonsukim@snu.ac.kr
FAU - Yang, Seung Hee
AU  - Yang SH
FAU - Kang, Hee Gyung
AU  - Kang HG
FAU - Seong, Eun Young
AU  - Seong EY
FAU - Lee, Se Han
AU  - Lee SH
FAU - Gao, Wenda
AU  - Gao W
FAU - Kenny, James
AU  - Kenny J
FAU - Zheng, Xin Xiao
AU  - Zheng XX
FAU - Strom, Terry B
AU  - Strom TB
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20061026
PL  - England
TA  - Int Immunol
JT  - International immunology
JID - 8916182
RN  - 0 (CD11c Antigen)
RN  - 0 (CD4 Antigens)
RN  - 0 (CD8 Antigens)
SB  - IM
MH  - Animals
MH  - CD11c Antigen/metabolism
MH  - CD4 Antigens/metabolism
MH  - CD8 Antigens/metabolism
MH  - Dendritic Cells/*cytology/transplantation
MH  - *Graft Survival/physiology
MH  - Humans
MH  - *Islets of Langerhans Transplantation
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Inbred DBA
MH  - Species Specificity
MH  - *Tissue Donors/classification
MH  - *Transplantation Tolerance
MH  - *Transplantation, Homologous
EDAT- 2006/10/28 09:00
MHDA- 2007/01/24 09:00
CRDT- 2006/10/28 09:00
PHST- 2006/10/28 09:00 [pubmed]
PHST- 2007/01/24 09:00 [medline]
PHST- 2006/10/28 09:00 [entrez]
AID - dxl111 [pii]
AID - 10.1093/intimm/dxl111 [doi]
PST - ppublish
SO  - Int Immunol. 2006 Dec;18(12):1771-7. doi: 10.1093/intimm/dxl111. Epub 2006 Oct 
      26.