PMID- 17070052
OWN - NLM
STAT- MEDLINE
DCOM- 20070108
LR  - 20191210
IS  - 1879-3088 (Electronic)
IS  - 0962-8924 (Linking)
VI  - 16
IP  - 12
DP  - 2006 Dec
TI  - ARDent about acetylation and deacetylation in hypoxia signalling.
PG  - 616-21
AB  - Given the key role that the alpha subunit of the alphabeta heterodimeric 
      transcription factor hypoxia-inducible factor-1 (HIF-1) has in tumourigenesis, 
      and in particular in angiogenesis, a full understanding of its regulation is 
      crucial to the development of cancer therapeutics. Posttranslational acetylation 
      and deacetylation of this subunit by an acetyltransferase called 
      Arrest-defective-1 (ARD1) and by different histone deacetylases (HDACs), 
      respectively, has been suggested as a mechanism. However, conflicting data bring 
      into question the foundations of this mechanism and at present it is not clear 
      what the precise role of these proteins is with respect to HIF. Nonetheless, the 
      observation that small-molecule inhibitors of HDACs have anti-angiogenic activity 
      suggests that acetylation and deacetylation of HIF or HIF modifiers represents a 
      potential target in cancer therapy.
FAU - Bilton, Rebecca
AU  - Bilton R
AD  - Institute of Signaling, Developmental Biology and Cancer Research CNRS UMR 6543, 
      University of Nice, Centre A. Lacassagne, 33 Avenue Valombrose, 06189 Nice, 
      France.
FAU - Trottier, Eric
AU  - Trottier E
FAU - Pouyssegur, Jacques
AU  - Pouyssegur J
FAU - Brahimi-Horn, M Christiane
AU  - Brahimi-Horn MC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061027
PL  - England
TA  - Trends Cell Biol
JT  - Trends in cell biology
JID - 9200566
RN  - 0 (Antineoplastic Agents)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Histone Deacetylase Inhibitors)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Protein Isoforms)
RN  - EC 2.3.1.- (Acetyltransferases)
RN  - EC 2.3.1.254 (N-Terminal Acetyltransferase A)
RN  - EC 2.3.1.255 (NAA10 protein, human)
RN  - EC 2.3.1.258 (N-Terminal Acetyltransferase E)
RN  - EC 3.5.1.98 (Histone Deacetylases)
SB  - IM
MH  - Acetylation/drug effects
MH  - Acetyltransferases/chemistry/genetics/*metabolism
MH  - Animals
MH  - Antineoplastic Agents/pharmacology
MH  - Cell Hypoxia/drug effects/*physiology
MH  - Drug Design
MH  - Histone Deacetylase Inhibitors
MH  - Histone Deacetylases/*metabolism
MH  - Humans
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism
MH  - N-Terminal Acetyltransferase A
MH  - N-Terminal Acetyltransferase E
MH  - Neoplasms/drug therapy/*metabolism/physiopathology
MH  - Protein Isoforms/chemistry/genetics/metabolism
MH  - Signal Transduction/drug effects/physiology
EDAT- 2006/10/31 09:00
MHDA- 2007/01/09 09:00
CRDT- 2006/10/31 09:00
PHST- 2006/06/07 00:00 [received]
PHST- 2006/09/22 00:00 [revised]
PHST- 2006/10/09 00:00 [accepted]
PHST- 2006/10/31 09:00 [pubmed]
PHST- 2007/01/09 09:00 [medline]
PHST- 2006/10/31 09:00 [entrez]
AID - S0962-8924(06)00272-8 [pii]
AID - 10.1016/j.tcb.2006.10.002 [doi]
PST - ppublish
SO  - Trends Cell Biol. 2006 Dec;16(12):616-21. doi: 10.1016/j.tcb.2006.10.002. Epub 
      2006 Oct 27.