PMID- 17070067
OWN - NLM
STAT- MEDLINE
DCOM- 20070126
LR  - 20151119
IS  - 1043-4666 (Print)
IS  - 1043-4666 (Linking)
VI  - 35
IP  - 5-6
DP  - 2006 Sep
TI  - Inflammation but not oxidative stress is associated with beta-chemokine levels 
      and prevalence of cardiovascular disease in uraemic patients.
PG  - 258-62
AB  - Inflammation and oxidative stress (SOX) have been reported in patients with 
      chronic renal failure (CRF), but their influence on beta-chemokines levels and 
      cardiovascular disease (CVD) prevalence remains unknown. We assessed 
      beta-chemokines, SOX markers and high sensitivity C-reactive protein (hs CRP) as 
      a marker of inflammation in 40 uraemic patients, both with as well as without CVD 
      and 20 controls. Compared with the controls, the patients with CVD showed a 
      significant increase in plasma concentrations of monocyte chemoattractant 
      protein-1 (MCP-1), total peroxide (both p<0.05), macrophage inflammatory protein 
      1beta (MIP-1beta) and hs CRP (both p<0.01). The values of MCP-1 and hs CRP were 
      more elevated in patients with CVD than without CVD (p<0.01 and p<0.05; 
      respectively). Both subgroup of CRF patients were lower of regulated upon 
      activation, normal T cell expressed and secreted (RANTES) levels than in the 
      controls (both p<0.001). The positive relationships were between hs CRP and 
      presence of CVD, MIP-1beta (both p<0.01) and MCP-1 levels (p<0.05). SOX markers 
      did not show any significant correlation with beta-chemokines, hs CRP and 
      presence of CVD. We documented that increased inflammation but not SOX were 
      associated with significant elevation in plasma beta-chemokines levels and CVD 
      prevalence in CRF patients not requiring dialysis.
FAU - Pawlak, Krystyna
AU  - Pawlak K
AD  - Department of Nephrology and Clinical Transplantation, Medical University, 14 
      Zurawia Street, 15-540 Bialystok, Poland. krystynapawlak@poczta.onet.pl
FAU - Pawlak, Dariusz
AU  - Pawlak D
FAU - Mysliwiec, Michal
AU  - Mysliwiec M
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
DEP - 20061027
PL  - England
TA  - Cytokine
JT  - Cytokine
JID - 9005353
RN  - 0 (Biomarkers)
RN  - 0 (Chemokines, CC)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Cardiovascular Diseases/*blood/complications/immunology
MH  - Chemokines, CC/*blood/immunology
MH  - Female
MH  - Humans
MH  - Inflammation/blood/immunology
MH  - Kidney Failure, Chronic/*blood/complications/metabolism
MH  - Male
MH  - Middle Aged
MH  - Oxidative Stress/immunology
MH  - Uremia/*blood/complications/immunology
EDAT- 2006/10/31 09:00
MHDA- 2007/01/27 09:00
CRDT- 2006/10/31 09:00
PHST- 2005/06/29 00:00 [received]
PHST- 2006/08/03 00:00 [revised]
PHST- 2006/09/13 00:00 [accepted]
PHST- 2006/10/31 09:00 [pubmed]
PHST- 2007/01/27 09:00 [medline]
PHST- 2006/10/31 09:00 [entrez]
AID - S1043-4666(06)00271-7 [pii]
AID - 10.1016/j.cyto.2006.09.004 [doi]
PST - ppublish
SO  - Cytokine. 2006 Sep;35(5-6):258-62. doi: 10.1016/j.cyto.2006.09.004. Epub 2006 Oct 
      27.