PMID- 17071632
OWN - NLM
STAT- MEDLINE
DCOM- 20070510
LR  - 20161124
IS  - 0143-3334 (Print)
IS  - 0143-3334 (Linking)
VI  - 28
IP  - 4
DP  - 2007 Apr
TI  - Apigenin inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF 
      expression.
PG  - 858-64
AB  - Apigenin is a non-toxic dietary flavonoid with anti-tumor properties. We recently 
      showed that apigenin-inhibited hypoxia-inducible factor-1 (HIF-1) and vascular 
      endothelial growth factor (VEGF) expression in human ovarian cancer cells under 
      normoxic condition. However, the effect of apigenin in angiogenesis remains to be 
      elucidated. Angiogenesis is the formation of new blood vessels and is required 
      for tumor growth and metastasis. In this study, we showed that apigenin-inhibited 
      expression of HIF-1 and VEGF in different cancer cells under both normoxic and 
      hypoxic conditions. We demonstrated that apigenin significantly inhibited tumor 
      angiogenesis in vivo, by using both the chicken chorioallantoic membrane and 
      Matrigel plug assays. The inhibition of tumor angiogenesis was associated with 
      the decrease of HIF-1 and VEGF in tumor tissues. Taken together, our results show 
      that apigenin suppresses tumor angiogenesis through HIF-1 and VEGF expression.
FAU - Fang, Jing
AU  - Fang J
AD  - The Institute for Nutritional Sciences, Shanghai Institute for Biological 
      Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
FAU - Zhou, Qiong
AU  - Zhou Q
FAU - Liu, Ling-Zhi
AU  - Liu LZ
FAU - Xia, Chang
AU  - Xia C
FAU - Hu, Xiaowen
AU  - Hu X
FAU - Shi, Xianglin
AU  - Shi X
FAU - Jiang, Bing-Hua
AU  - Jiang BH
LA  - eng
PT  - Journal Article
DEP - 20061027
PL  - England
TA  - Carcinogenesis
JT  - Carcinogenesis
JID - 8008055
RN  - 0 (Drug Combinations)
RN  - 0 (HIF1A protein, human)
RN  - 0 (Hif1a protein, mouse)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Laminin)
RN  - 0 (Proteoglycans)
RN  - 0 (VEGFA protein, human)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 119978-18-6 (matrigel)
RN  - 7V515PI7F6 (Apigenin)
RN  - 9007-34-5 (Collagen)
SB  - IM
MH  - Animals
MH  - Apigenin/*pharmacology
MH  - Apoptosis/drug effects
MH  - Binding Sites
MH  - Cell Division/drug effects
MH  - Cell Line, Tumor
MH  - Chick Embryo
MH  - Chorioallantoic Membrane/drug effects/metabolism
MH  - Collagen/metabolism
MH  - Drug Combinations
MH  - Female
MH  - Flow Cytometry
MH  - Gene Expression Regulation, Neoplastic/drug effects
MH  - Humans
MH  - Hypoxia
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/antagonists & inhibitors/*metabolism
MH  - Laminin/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Nude
MH  - Neoplasms, Experimental/*blood supply/metabolism
MH  - Neovascularization, Pathologic/*prevention & control
MH  - Promoter Regions, Genetic
MH  - Proteoglycans/metabolism
MH  - Signal Transduction
MH  - Vascular Endothelial Growth Factor A/antagonists & 
      inhibitors/genetics/*metabolism
EDAT- 2006/10/31 09:00
MHDA- 2007/05/11 09:00
CRDT- 2006/10/31 09:00
PHST- 2006/10/31 09:00 [pubmed]
PHST- 2007/05/11 09:00 [medline]
PHST- 2006/10/31 09:00 [entrez]
AID - bgl205 [pii]
AID - 10.1093/carcin/bgl205 [doi]
PST - ppublish
SO  - Carcinogenesis. 2007 Apr;28(4):858-64. doi: 10.1093/carcin/bgl205. Epub 2006 Oct 
      27.