PMID- 17071929
OWN - NLM
STAT- MEDLINE
DCOM- 20061204
LR  - 20181113
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 80
IP  - 22
DP  - 2006 Nov
TI  - Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic 
      hepatitis C virus infection.
PG  - 11094-104
AB  - Cellular immune responses are an important correlate of hepatitis C virus (HCV) 
      infection outcome. These responses are governed by the host's human leukocyte 
      antigen (HLA) type, and HLA-restricted viral escape mutants are a critical aspect 
      of this host-virus interaction. We examined the driving forces of HCV evolution 
      by characterizing the in vivo selective pressure(s) exerted on single amino acid 
      residues within nonstructural protein 3 (NS3) by the HLA types present in two 
      host populations. Associations between polymorphisms within NS3 and HLA class I 
      alleles were assessed in 118 individuals from Western Australia and Switzerland 
      with chronic hepatitis C infection, of whom 82 (69%) were coinfected with human 
      immunodeficiency virus. The levels and locations of amino acid polymorphisms 
      exhibited within NS3 were remarkably similar between the two cohorts and revealed 
      regions under functional constraint and selective pressures. We identified 
      specific HCV mutations within and flanking published epitopes with the correct 
      HLA restriction and predicted escaped amino acid. Additional HLA-restricted 
      mutations were identified that mark putative epitopes targeted by cell-mediated 
      immune responses. This analysis of host-virus interaction reveals evidence of HCV 
      adaptation to HLA class I-restricted immune pressure and identifies in vivo 
      targets of cellular immune responses at the population level.
FAU - Gaudieri, Silvana
AU  - Gaudieri S
AD  - Centre for Clinical Immunology and Biomedical Statistics, Level 2, North Block, 
      Royal Perth Hospital, Wellington St., Perth, Western Australia 6000, Australia.
FAU - Rauch, Andri
AU  - Rauch A
FAU - Park, Lawrence P
AU  - Park LP
FAU - Freitas, Elizabeth
AU  - Freitas E
FAU - Herrmann, Susan
AU  - Herrmann S
FAU - Jeffrey, Gary
AU  - Jeffrey G
FAU - Cheng, Wendy
AU  - Cheng W
FAU - Pfafferott, Katja
AU  - Pfafferott K
FAU - Naidoo, Kiloshni
AU  - Naidoo K
FAU - Chapman, Russell
AU  - Chapman R
FAU - Battegay, Manuel
AU  - Battegay M
FAU - Weber, Rainer
AU  - Weber R
FAU - Telenti, Amalio
AU  - Telenti A
FAU - Furrer, Hansjakob
AU  - Furrer H
FAU - James, Ian
AU  - James I
FAU - Lucas, Michaela
AU  - Lucas M
FAU - Mallal, Simon A
AU  - Mallal SA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Epitopes)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (NS3 protein, hepatitis C virus)
RN  - 0 (Viral Nonstructural Proteins)
SB  - IM
EIN - J Virol. 2007 Aug;81(16):8846-8
MH  - *Adaptation, Biological
MH  - Amino Acid Substitution
MH  - DNA Mutational Analysis
MH  - Epitopes/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genes, MHC Class I
MH  - Hepacivirus/*genetics/*immunology/isolation & purification
MH  - Hepatitis C, Chronic/*immunology/*virology
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Male
MH  - Models, Molecular
MH  - Mutation, Missense
MH  - Phylogeny
MH  - Polymorphism, Genetic
MH  - *Selection, Genetic
MH  - Sequence Homology, Amino Acid
MH  - Statistics as Topic
MH  - Viral Nonstructural Proteins/genetics
PMC - PMC1642167
EDAT- 2006/10/31 09:00
MHDA- 2006/12/09 09:00
PMCR- 2007/03/01
CRDT- 2006/10/31 09:00
PHST- 2006/10/31 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/10/31 09:00 [entrez]
PHST- 2007/03/01 00:00 [pmc-release]
AID - 80/22/11094 [pii]
AID - 0912-06 [pii]
AID - 10.1128/JVI.00912-06 [doi]
PST - ppublish
SO  - J Virol. 2006 Nov;80(22):11094-104. doi: 10.1128/JVI.00912-06.