PMID- 17072276
OWN - NLM
STAT- MEDLINE
DCOM- 20070307
LR  - 20161124
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 12
IP  - 11
DP  - 2006 Nov
TI  - 3,4-methylenedioxymethamphetamine (MDMA): an important cause of acute hepatitis.
PG  - CS107-9
AB  - BACKGROUND: MDMA, i.e. 3,4-methylenedioxymethamphetamine ("Ecstasy"), 
      occasionally produces significant hepatotoxicity in humans. It is characterized 
      by a wide range of variability in clinical expression, ranging from asymptomatic 
      liver injury, as observed by altered liver function tests, to acute hepatic 
      failure. Prognostic factors that may predict the outcome of this condition remain 
      unknown. CASE REPORT: We report a case of a 19-year-old male who presented 
      deeplyjaundiced two weeks after ingestion of two tablets of Ecstasy. The clinical 
      picture, laboratory data, and morphological studies were consistent with acute 
      hepatitis. There was no evidence for a viral, alcoholic, metabolic, or autoimmune 
      etiology of the disease. A mild clinical course with complete recovery after two 
      months was observed. The presence of All molecule was confirmed in the patient. 
      CONCLUSIONS: The possible association of specific human leukocyte antigen (HLA) 
      phenotypes and MDMA-induced hepatotoxicity needs future evaluation.
FAU - Brncic, Nada
AU  - Brncic N
AD  - Department of Infectious Diseases, University Hospital Center, Rijeka, Croatia. 
      nada.brncic@medri.hr
FAU - Kraus, Ivan
AU  - Kraus I
FAU - Viskovic, Ivica
AU  - Viskovic I
FAU - Mijandrusic-Sincic, Brankica
AU  - Mijandrusic-Sincic B
FAU - Vlahovic-Palcevski, Vera
AU  - Vlahovic-Palcevski V
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
RN  - 0 (HLA Antigens)
RN  - 0 (Hallucinogens)
RN  - EC 2.6.1.1 (Aspartate Aminotransferases)
RN  - EC 2.6.1.2 (Alanine Transaminase)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Adult
MH  - Alanine Transaminase/metabolism
MH  - Aspartate Aminotransferases/metabolism
MH  - Bilirubin/metabolism
MH  - Chemical and Drug Induced Liver Injury/*diagnosis/*etiology
MH  - HLA Antigens/biosynthesis
MH  - Hallucinogens/*toxicity
MH  - Humans
MH  - Liver/*drug effects/pathology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*toxicity
MH  - Phenotype
MH  - Prognosis
MH  - Time Factors
EDAT- 2006/10/31 09:00
MHDA- 2007/03/08 09:00
CRDT- 2006/10/31 09:00
PHST- 2006/01/03 00:00 [received]
PHST- 2006/04/20 00:00 [accepted]
PHST- 2006/10/31 09:00 [pubmed]
PHST- 2007/03/08 09:00 [medline]
PHST- 2006/10/31 09:00 [entrez]
AID - 8617 [pii]
PST - ppublish
SO  - Med Sci Monit. 2006 Nov;12(11):CS107-9.