PMID- 17072848
OWN - NLM
STAT- MEDLINE
DCOM- 20070206
LR  - 20181201
IS  - 1549-3296 (Print)
IS  - 1549-3296 (Linking)
VI  - 80
IP  - 1
DP  - 2007 Jan
TI  - Transfer of apatite coating from porogens to scaffolds: uniform apatite coating 
      within porous poly(DL-lactic-co-glycolic acid) scaffold in vitro.
PG  - 226-33
AB  - Strategies to bone tissue engineering have focused on the use of synthetic or 
      natural degradable materials as scaffolds for cell transplantation to guide bone 
      regeneration. Biocompatibility, biodegradability, biomechanical integrity, and 
      osteoconductivity are important requirements for the scaffold materials. This 
      study explored a new approach of apatite coating to enhance the osteoconductivity 
      of a synthetic degradable poly(DL-lactic-co-glycolic acid) (PLGA) scaffold. The 
      new approach was developed to ensure a relatively uniform apatite coating on the 
      interior pore surfaces deep inside a scaffold, even for a relatively thick 
      scaffold with small pores. Apatite was first coated on the surface of paraffin 
      spheres of the desirable sizes. The paraffin spheres were then molded to form a 
      foam. PLGA/pyridine solution was cast into the interspaces among the paraffin 
      spheres. After the paraffin spheres were dissolved and removed by cyclohexane, 
      PLGA scaffold with controlled pore size, good interconnectivity and high porosity 
      was obtained with apatite left on the pore surface uniformly throughout the whole 
      scaffold. The scaffold and apatite coating were characterized using 
      thermogravimetry analysis, scanning electron microscopy, energy dispersive X-ray 
      spectroscopy, and X-ray diffractometry.
CI  - (c) 2006 Wiley Periodicals, Inc.
FAU - Li, Jiashen
AU  - Li J
AD  - Department of Health Technology and Informatics, The Hong Kong Polytechnic 
      University, Hong Hum, Kowloon, Hong Kong, China.
FAU - Beaussart, Audrey
AU  - Beaussart A
FAU - Chen, Yun
AU  - Chen Y
FAU - Mak, Arthur F T
AU  - Mak AF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biomed Mater Res A
JT  - Journal of biomedical materials research. Part A
JID - 101234237
RN  - 0 (Coated Materials, Biocompatible)
RN  - 0 (Polymers)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - *Bone Regeneration
MH  - *Coated Materials, Biocompatible/chemistry
MH  - *Lactic Acid/chemistry
MH  - Microscopy, Electron, Scanning
MH  - Microspheres
MH  - *Polyglycolic Acid/chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - *Polymers/chemistry
MH  - Porosity
MH  - Tissue Engineering
EDAT- 2006/10/31 09:00
MHDA- 2007/02/07 09:00
CRDT- 2006/10/31 09:00
PHST- 2006/10/31 09:00 [pubmed]
PHST- 2007/02/07 09:00 [medline]
PHST- 2006/10/31 09:00 [entrez]
AID - 10.1002/jbm.a.31096 [doi]
PST - ppublish
SO  - J Biomed Mater Res A. 2007 Jan;80(1):226-33. doi: 10.1002/jbm.a.31096.