PMID- 17074054
OWN - NLM
STAT- MEDLINE
DCOM- 20061221
LR  - 20131121
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 24
IP  - 8
DP  - 2006 Oct
TI  - Dietary restriction changes behaviours in brain-derived neurotrophic factor 
      heterozygous mice: role of serotonergic system.
PG  - 2335-44
AB  - Accumulating evidence has suggested that brain-derived neurotrophic factor (BDNF) 
      plays a role in eating behaviours, and that BDNF-heterozygous (+/-) mice exhibit 
      abnormal behaviours (e.g. obesity, anxiety and aggression). The present study was 
      undertaken to determine whether or not dietary restriction (DR) alters the 
      behaviours in BDNF(+/-) mice, as DR has been shown to exert a number of 
      beneficial effects on the brain. Eight-week-old male wild-type (+/+) and 
      BDNF(+/-) mice were divided into two groups, ad libitum (AL) diet group and DR 
      group, for 16 weeks. After carrying out a behavioural evaluation, we determined 
      the BDNF mRNA levels, as well as mRNA levels for subtypes (5-HT(1A), 5-HT(1B), 
      5-HT(2A) and 5-HT(2C)) of the 5-HT receptor and 5-HT transporter (5-HTT), protein 
      levels of BDNF and concentrations of 5-HT and 5-HIAA in the hypothalamus, 
      hippocampus and frontal cortex. DR significantly ameliorated behaviours including 
      obesity, anxiety and aggression in BDNF(+/-) mice. The concentrations of 5-HT and 
      5-HIAA in the frontal cortex, and 5-HT in the hippocampus, of BDNF(+/-) mice were 
      significantly lower than those of wild-type mice. Interestingly, DR significantly 
      increased the levels of 5-HT and 5-HIAA in the frontal cortex of BDNF(+/-) mice. 
      These findings suggest that DR may alter the behaviours in BDNF(+/-) mice, and 
      that the 5-HT system may be implicated in the beneficial effects of DR on these 
      behaviours.
FAU - Koizumi, Hiroki
AU  - Koizumi H
AD  - Department of Psychiatry, Chiba University Graduate School of Medicine, Chiba, 
      Japan.
FAU - Hashimoto, Kenji
AU  - Hashimoto K
FAU - Iyo, Masaomi
AU  - Iyo M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - 333DO1RDJY (Serotonin)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
SB  - IM
MH  - Aggression/physiology
MH  - Animals
MH  - Anxiety/psychology
MH  - Behavior, Animal/*physiology
MH  - Body Weight/physiology
MH  - Brain-Derived Neurotrophic Factor/*genetics/metabolism
MH  - Chromatography, High Pressure Liquid
MH  - Data Interpretation, Statistical
MH  - Eating/physiology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Exploratory Behavior/physiology
MH  - Food Deprivation/*physiology
MH  - Heterozygote
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Obesity/physiopathology/psychology
MH  - RNA, Messenger/biosynthesis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Serotonin/metabolism/*physiology
EDAT- 2006/11/01 09:00
MHDA- 2006/12/22 09:00
CRDT- 2006/11/01 09:00
PHST- 2006/11/01 09:00 [pubmed]
PHST- 2006/12/22 09:00 [medline]
PHST- 2006/11/01 09:00 [entrez]
AID - EJN5094 [pii]
AID - 10.1111/j.1460-9568.2006.05094.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2006 Oct;24(8):2335-44. doi: 10.1111/j.1460-9568.2006.05094.x.