PMID- 17074459
OWN - NLM
STAT- MEDLINE
DCOM- 20070403
LR  - 20191210
IS  - 0720-048X (Print)
IS  - 0720-048X (Linking)
VI  - 61
IP  - 2
DP  - 2007 Feb
TI  - A multicenter, site-independent, blinded study to compare the diagnostic accuracy 
      of contrast-enhanced magnetic resonance angiography using 1.0M gadobutrol 
      (Gadovist) to intraarterial digital subtraction angiography in body arteries.
PG  - 315-23
AB  - PURPOSE: Prospective evaluation of diagnostic accuracy of single field-of-view 
      contrast-enhanced MR Angiography (ceMRA) with 1.0M gadobutrol compared to 
      intraarterial DSA in body arteries. MATERIALS AND METHODS: In an European 
      multicenter study 179 patients underwent ceMRA and DSA. For each indication five 
      prospectively defined vessel segments were evaluated by local investigators 
      onsite and by three site-independent blinded readers (BR) independently. RESULTS: 
      The agreement between ceMRA and DSA diagnosis was statistically significant in 
      the onsite (96.6%) and blinded reader (86.6-90.2%) evaluation. Sensitivity, 
      specificity, accuracy, positive (PPV) and negative predictive values (NPV) for 
      detection of relevant stenosis (>50%) were calculated for the right and left 
      internal carotid arteries, and common and external iliac arteries: Sensitivity 
      was 95-98% (onsite) and 76-96% (BR), specificity 94-96% (onsite) and 86-94% (BR), 
      accuracy 96% (onsite) and 87-93% (BR), NPV 98-99% (onsite) and 84-98% (BR), and 
      PPV 79-93% (onsite) and 44-91% (BR), respectively. CONCLUSION: CeMRA of body 
      arteries using 1.0M gadobutrol provides diagnostic information comparable to 
      intraarterial DSA.
FAU - Schaefer, Fritz K W
AU  - Schaefer FK
AD  - Department of Diagnostic Radiology, University Hospital Schleswig-Holstein Campus 
      Kiel, Arnold-Heller-Strasse 9, 24105 Kiel, Germany. fschaefer@email.uni-kiel.de
FAU - Schaefer, Philipp J
AU  - Schaefer PJ
FAU - Altjohann, Christian
AU  - Altjohann C
FAU - Bourne, Michael
AU  - Bourne M
FAU - Decobelli, Francesco
AU  - Decobelli F
FAU - Goyen, Mathias
AU  - Goyen M
FAU - Griffiths, Paul D
AU  - Griffiths PD
FAU - Kopka, Lars
AU  - Kopka L
FAU - Kreitner, Karl F
AU  - Kreitner KF
FAU - Link, Johann
AU  - Link J
FAU - Oberholzer, Katja
AU  - Oberholzer K
FAU - Pering, Christiane
AU  - Pering C
FAU - Poeckler-Schoeninger, Christiane
AU  - Poeckler-Schoeninger C
FAU - Ruehm, Stefan G
AU  - Ruehm SG
FAU - Sachoran, Mansur R
AU  - Sachoran MR
FAU - Schulte-Altedorneburg, Gernot
AU  - Schulte-Altedorneburg G
FAU - Springer, Oliver S
AU  - Springer OS
FAU - Steiner, Paul
AU  - Steiner P
FAU - Wall, Alexander
AU  - Wall A
FAU - Winterer, Jan
AU  - Winterer J
FAU - Tombach, Bernd
AU  - Tombach B
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20061030
PL  - Ireland
TA  - Eur J Radiol
JT  - European journal of radiology
JID - 8106411
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Angiography, Digital Subtraction
MH  - Arteries/*pathology
MH  - Constriction, Pathologic/diagnosis
MH  - Contrast Media
MH  - Gadolinium
MH  - Humans
MH  - Magnetic Resonance Angiography/*methods
MH  - Male
MH  - Middle Aged
MH  - Organometallic Compounds
MH  - Prospective Studies
MH  - Sensitivity and Specificity
MH  - Single-Blind Method
EDAT- 2006/11/01 09:00
MHDA- 2007/04/04 09:00
CRDT- 2006/11/01 09:00
PHST- 2006/06/14 00:00 [received]
PHST- 2006/09/02 00:00 [revised]
PHST- 2006/09/08 00:00 [accepted]
PHST- 2006/11/01 09:00 [pubmed]
PHST- 2007/04/04 09:00 [medline]
PHST- 2006/11/01 09:00 [entrez]
AID - S0720-048X(06)00390-1 [pii]
AID - 10.1016/j.ejrad.2006.09.002 [doi]
PST - ppublish
SO  - Eur J Radiol. 2007 Feb;61(2):315-23. doi: 10.1016/j.ejrad.2006.09.002. Epub 2006 
      Oct 30.