PMID- 17074682
OWN - NLM
STAT- MEDLINE
DCOM- 20070104
LR  - 20151119
IS  - 0002-9173 (Print)
IS  - 0002-9173 (Linking)
VI  - 126
IP  - 6
DP  - 2006 Dec
TI  - p16INK4A (CDKN2A) gene deletion is a frequent genetic event in synovial sarcomas.
PG  - 866-74
AB  - We assessed the frequency of genomic deletion of p16INK4A (CDKN2A) in synovial 
      sarcomas (SSs) and its possible association with immunoexpression of p16 and 
      cyclin D1 and the Ki-67 proliferation index using dual-color fluorescence in situ 
      hybridization (FISH) on tissue microarray sections of 41 histologically and 
      molecularly confirmed SSs. A heterozygous p16INK4A gene deletion was identified 
      in 28 (74%) of 38 cases, with 25 (89%) of them showing abnormal p16 protein 
      expression (20 negative and 5 heterogeneous). Of 25 cases, 19 (76%) exhibiting 
      increased cyclin D1expression also demonstrated heterozygous p16INK4A deletion. 
      No significant association was observed between p16INK4A deletion and Ki-67 
      proliferation index, tumor grade, or histologic subtype. Our results demonstrate 
      that p16INK4A (CDKN2A) gene deletion is a frequent genetic event in SS.
FAU - Subramaniam, Manish M
AU  - Subramaniam MM
AD  - Department of Pathology, Medical School, University of Valencia, Spain.
FAU - Noguera, Rosa
AU  - Noguera R
FAU - Piqueras, Marta
AU  - Piqueras M
FAU - Navarro, Samuel
AU  - Navarro S
FAU - Lopez-Guerrero, Jose A
AU  - Lopez-Guerrero JA
FAU - Llombart-Bosch, Antonio
AU  - Llombart-Bosch A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Cyclin D)
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
RN  - 0 (Cyclins)
RN  - 0 (Ki-67 Antigen)
SB  - IM
MH  - Biomarkers, Tumor/metabolism
MH  - Cell Nucleus/metabolism/pathology
MH  - Cyclin D
MH  - Cyclin-Dependent Kinase Inhibitor p16/*genetics/metabolism
MH  - Cyclins/metabolism
MH  - *Gene Deletion
MH  - Heterozygote
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Ki-67 Antigen/metabolism
MH  - Sarcoma, Synovial/*genetics/metabolism/pathology
MH  - Soft Tissue Neoplasms/*genetics/metabolism/pathology
MH  - Tissue Array Analysis
EDAT- 2006/11/01 09:00
MHDA- 2007/01/05 09:00
CRDT- 2006/11/01 09:00
PHST- 2006/11/01 09:00 [pubmed]
PHST- 2007/01/05 09:00 [medline]
PHST- 2006/11/01 09:00 [entrez]
AID - E2AAY2XXN431WL81 [pii]
AID - 10.1309/E2AAY2XXN431WL81 [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2006 Dec;126(6):866-74. doi: 10.1309/E2AAY2XXN431WL81.