PMID- 17077598
OWN - NLM
STAT- MEDLINE
DCOM- 20070109
LR  - 20190727
IS  - 0040-8727 (Print)
IS  - 0040-8727 (Linking)
VI  - 210
IP  - 3
DP  - 2006 Nov
TI  - Improvement of psychiatric symptoms after electroconvulsive therapy in young 
      adults with intractable first-episode schizophrenia and schizophreniform 
      disorder.
PG  - 213-20
AB  - Schizophrenia is a serious psychiatric disorder that develops mainly in young 
      adults. Electroconvulsive therapy (ECT) is known to be effective and safe in 
      patients with schizophrenia with acute psychotic exacerbation. Because of the 
      shortage of systematic studies, we conducted a prospective naturalistic study to 
      examine the short-term effects of acute ECT and its safety in young adults with 
      medically intractable first-episode schizophrenia. Subjects were seven 
      consecutive patients, 15-35 years of age, with first-episode schizophrenia or 
      schizophreniform disorder (Diagnostic and Statistical Manual of Mental Disorders, 
      4th edition; DSM-IV), who had failed to respond to neuroleptics. The seven 
      patients were treated with a first course of ECT, and their clinical symptoms 
      were evaluated on the basis of the Brief Psychiatric Rating Scale (BPRS) (18 
      items, rated 0-6) and Global Assessment of Functioning (GAF) Scale. The GAF Scale 
      is presented in DSM-IV as a means of assessing global functioning of a 
      psychiatric patient. Scores range from 1-100; the higher GAF score indicates the 
      higher global functioning. Adverse effects resulting from acute ECT were also 
      evaluated. The total BPRS score 1 week after the final session improved 
      significantly compared to the total pre-ECT BPRS score. The GAF score also 
      improved significantly compared to the pre-ECT GAF score. There were no adverse 
      effects during the acute ECT course, except for mild delirium. We conclude that 
      ECT may be an effective and safe treatment option for young adults with 
      intractable first-episode schizophrenia.
FAU - Suzuki, Kazumasa
AU  - Suzuki K
AD  - Department of Psychiatry, Tohoku University Hospital, Sendai, Japan. 
      kazumasa-tohoku@umin.ac.jp
FAU - Awata, Shuichi
AU  - Awata S
FAU - Takano, Takehisa
AU  - Takano T
FAU - Ebina, Yukio
AU  - Ebina Y
FAU - Takamatsu, Kosei
AU  - Takamatsu K
FAU - Kajiwara, Toshihiko
AU  - Kajiwara T
FAU - Ito, Kae
AU  - Ito K
FAU - Shindo, Tsuyoshi
AU  - Shindo T
FAU - Funakoshi, Shunichi
AU  - Funakoshi S
FAU - Matsuoka, Hiroo
AU  - Matsuoka H
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Tohoku J Exp Med
JT  - The Tohoku journal of experimental medicine
JID - 0417355
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Electroconvulsive Therapy/*methods
MH  - Female
MH  - Humans
MH  - Male
MH  - Psychotic Disorders/*therapy
MH  - Schizophrenia/*therapy
MH  - Treatment Outcome
EDAT- 2006/11/02 09:00
MHDA- 2007/01/11 09:00
CRDT- 2006/11/02 09:00
PHST- 2006/11/02 09:00 [pubmed]
PHST- 2007/01/11 09:00 [medline]
PHST- 2006/11/02 09:00 [entrez]
AID - JST.JSTAGE/tjem/210.213 [pii]
AID - 10.1620/tjem.210.213 [doi]
PST - ppublish
SO  - Tohoku J Exp Med. 2006 Nov;210(3):213-20. doi: 10.1620/tjem.210.213.