PMID- 17077617
OWN - NLM
STAT- MEDLINE
DCOM- 20070126
LR  - 20190724
IS  - 0031-6903 (Print)
IS  - 0031-6903 (Linking)
VI  - 126
IP  - 11
DP  - 2006 Nov
TI  - [Analysis of the factors associated with drugs remaining in the Diskhaler 
      following inhalation of fluticasone propionate].
PG  - 1163-9
AB  - Because it is well known that drug remains in the fluticasone propionate 
      Diskhaler (FP-DH) following a single inhalation, the following patient 
      information is recommended. "Please inhale more than once or twice if any drug 
      remains in the device after inhalation". It is believed the inspiratory flow rate 
      of the individual patient has an influence on the amount of drug that remains in 
      the device. If the dosing performance of FP-DH is dependent on inspiratory 
      effort, establishment of a method of inhalation that makes it independent of 
      inspiratory flow rate is important in clinical practice. In the present study, we 
      investigated the influence of various methods of inhalation of drug remaining in 
      the FP-DH. No significant differences were observed regarding the drug remaining 
      in the device among the inhalation times examined (range, 0.5-2.5 s) or the 
      number of inhalations (range, 1-3 times). On the other hand, the amount of drug 
      remaining in the device did decrease by tapping the device before the second 
      inhalation. The results suggest that the amount of drug remaining in the device 
      can be decreased by tapping the device after the first inhalation if the 
      patient's inspiratory flow rate is low.
FAU - Yokoyama, Haruko
AU  - Yokoyama H
AD  - Department of Clinical Drug Evaluation, School of Pharmacy, Tokyo University of 
      Pharmacy and Life Science, 1432-1 Horinouchi, Hachioji City 192-0392, Japan. 
      yokoyama@ps.toyaku.ac.jp
FAU - Yamamura, Yoshikazu
AU  - Yamamura Y
FAU - Ozeki, Takeshi
AU  - Ozeki T
FAU - Takayanagi, Risa
AU  - Takayanagi R
FAU - Iga, Tatsuji
AU  - Iga T
FAU - Yamada, Yasuhiko
AU  - Yamada Y
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PL  - Japan
TA  - Yakugaku Zasshi
JT  - Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
JID - 0413613
RN  - 0 (Androstadienes)
RN  - 0 (Bronchodilator Agents)
RN  - CUT2W21N7U (Fluticasone)
SB  - IM
MH  - Administration, Inhalation
MH  - Androstadienes/*administration & dosage/*analysis
MH  - Bronchodilator Agents/*administration & dosage/*analysis
MH  - *Drug Information Services
MH  - Female
MH  - Fluticasone
MH  - Humans
MH  - Inhalation/*physiology
MH  - Male
MH  - *Metered Dose Inhalers
MH  - Pulmonary Ventilation/*physiology
MH  - Time Factors
EDAT- 2006/11/02 09:00
MHDA- 2007/01/27 09:00
CRDT- 2006/11/02 09:00
PHST- 2006/11/02 09:00 [pubmed]
PHST- 2007/01/27 09:00 [medline]
PHST- 2006/11/02 09:00 [entrez]
AID - JST.JSTAGE/yakushi/126.1163 [pii]
AID - 10.1248/yakushi.126.1163 [doi]
PST - ppublish
SO  - Yakugaku Zasshi. 2006 Nov;126(11):1163-9. doi: 10.1248/yakushi.126.1163.