PMID- 1707820
OWN - NLM
STAT- MEDLINE
DCOM- 19910523
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 191
IP  - 3
DP  - 1990 Dec 4
TI  - Impaired cyclic AMP generation in outer medullary tubules of gentamicin-treated 
      rats.
PG  - 489-92
AB  - We have examined the effects of chronic gentamicin treatment on 
      arginine8-vasopressin (AVP)-dependent cyclic AMP (cAMP) metabolism in rat 
      medullary collecting tubules (oMCT) and medullary thick ascending limbs of 
      Henle's loop (mTALH). Gentamicin attenuated AVP-stimulated cAMP accumulation to a 
      greater extent in the mTALH (delta -51%) than in the oMCT (delta -25%). The 
      mechanism of attenuation differed between segments, and could not be attributed 
      to either direct inhibition of adenylate cyclase activity nor direct potentiation 
      of cAMP-phosphodiesterase activity. These data suggest that the 
      gentamicin-induced decrease in renal concentrating ability may be due at least in 
      part to reduced AVP-dependent cAMP accumulation in the oMCT and mTALH.
FAU - Kidwell, D
AU  - Kidwell D
AD  - Department of Physiology and Biophysics, University of Kentucky College of 
      Medicine, Lexington 40536-0084.
FAU - Subramaniam, S
AU  - Subramaniam S
FAU - Ott, C
AU  - Ott C
FAU - Jackson, B
AU  - Jackson B
LA  - eng
GR  - RR05374/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Gentamicins)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 1F7A44V6OU (Colforsin)
RN  - E0399OZS9N (Cyclic AMP)
RN  - EC 3.1.4.17 (3',5'-Cyclic-AMP Phosphodiesterases)
RN  - EC 4.6.1.1 (Adenylyl Cyclases)
RN  - TBT296U68M (1-Methyl-3-isobutylxanthine)
SB  - IM
MH  - 1-Methyl-3-isobutylxanthine/pharmacology
MH  - 3',5'-Cyclic-AMP Phosphodiesterases/metabolism
MH  - Adenylyl Cyclases/metabolism
MH  - Animals
MH  - Arginine Vasopressin/antagonists & inhibitors/pharmacology
MH  - Colforsin/pharmacology
MH  - Cyclic AMP/*biosynthesis
MH  - Depression, Chemical
MH  - Gentamicins/*pharmacology
MH  - Kidney Medulla/drug effects/*metabolism
MH  - Kidney Tubules, Distal/drug effects/*metabolism
MH  - Loop of Henle/drug effects/metabolism
MH  - Male
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1990/12/04 00:00
MHDA- 1990/12/04 00:01
CRDT- 1990/12/04 00:00
PHST- 1990/12/04 00:00 [pubmed]
PHST- 1990/12/04 00:01 [medline]
PHST- 1990/12/04 00:00 [entrez]
AID - 0014-2999(90)94186-2 [pii]
AID - 10.1016/0014-2999(90)94186-2 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1990 Dec 4;191(3):489-92. doi: 10.1016/0014-2999(90)94186-2.