PMID- 17079324
OWN - NLM
STAT- MEDLINE
DCOM- 20070212
LR  - 20181113
IS  - 0022-538X (Print)
IS  - 1098-5514 (Electronic)
IS  - 0022-538X (Linking)
VI  - 81
IP  - 1
DP  - 2007 Jan
TI  - Differential induction of type I interferon responses in myeloid dendritic cells 
      by mosquito and mammalian-cell-derived alphaviruses.
PG  - 237-47
AB  - Dendritic cells (DCs) are an important early target cell for many mosquito-borne 
      viruses, and in many cases mosquito-cell-derived arboviruses more efficiently 
      infect DCs than viruses derived from mammalian cells. However, whether 
      mosquito-cell-derived viruses differ from mammalian-cell-derived viruses in their 
      ability to induce antiviral responses in the infected dendritic cell has not been 
      evaluated. In this report, alphaviruses, which are mosquito-borne viruses that 
      cause diseases ranging from encephalitis to arthritis, were used to determine 
      whether viruses grown in mosquito cells differed from mammalian-cell-derived 
      viruses in their ability to induce type I interferon (IFN) responses in infected 
      primary dendritic cells. Consistent with previous results, mosquito-cell-derived 
      Ross River virus (mos-RRV) and Venezuelan equine encephalitis virus (mos-VEE) 
      exhibited enhanced infection of primary myeloid dendritic cells (mDCs) compared 
      to mammalian-cell-derived virus preparations. However, unlike the 
      mammalian-cell-derived viruses, which induced high levels of type I IFN in the 
      infected mDC cultures, mos-RRV and mos-VEE were poor IFN inducers. Furthermore, 
      the poor IFN induction by mos-RRV contributed to the enhanced infection of mDCs 
      by mos-RRV. These results suggest that the viruses initially delivered by the 
      mosquito vector differ from those generated in subsequent rounds of replication 
      in the host, not just with respect to their ability to infect dendritic cells but 
      also in their ability to induce or inhibit antiviral type I IFN responses. This 
      difference may have an important impact on the mosquito-borne virus's ability to 
      successfully make the transition from the arthropod vector to the vertebrate 
      host.
FAU - Shabman, Reed S
AU  - Shabman RS
AD  - Department of Genetics, The Carolina Vaccine Institute, The University of North 
      Carolina, Chapel Hill, NC 27599, USA.
FAU - Morrison, Thomas E
AU  - Morrison TE
FAU - Moore, Christopher
AU  - Moore C
FAU - White, Laura
AU  - White L
FAU - Suthar, Mehul S
AU  - Suthar MS
FAU - Hueston, Linda
AU  - Hueston L
FAU - Rulli, Nestor
AU  - Rulli N
FAU - Lidbury, Brett
AU  - Lidbury B
FAU - Ting, Jenny P-Y
AU  - Ting JP
FAU - Mahalingam, Suresh
AU  - Mahalingam S
FAU - Heise, Mark T
AU  - Heise MT
LA  - eng
GR  - F32 AR052600/AR/NIAMS NIH HHS/United States
GR  - R01 AR047190/AR/NIAMS NIH HHS/United States
GR  - F32AR052600-02/AR/NIAMS NIH HHS/United States
GR  - R01 AR47190-05/AR/NIAMS NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20061101
PL  - United States
TA  - J Virol
JT  - Journal of virology
JID - 0113724
RN  - 0 (Interferon Type I)
SB  - IM
MH  - Alphavirus/growth & development/*immunology/pathogenicity
MH  - Animals
MH  - Cells, Cultured
MH  - Culicidae/*virology
MH  - Dendritic Cells/*immunology/virology
MH  - Glycosylation
MH  - Humans
MH  - Insect Vectors/*virology
MH  - Interferon Type I/*biosynthesis
MH  - Mice
MH  - Myeloid Cells/*immunology/virology
MH  - Ross River virus/growth & development/*immunology/pathogenicity
PMC - PMC1797231
EDAT- 2006/11/03 09:00
MHDA- 2007/02/13 09:00
PMCR- 2007/05/01
CRDT- 2006/11/03 09:00
PHST- 2006/11/03 09:00 [pubmed]
PHST- 2007/02/13 09:00 [medline]
PHST- 2006/11/03 09:00 [entrez]
PHST- 2007/05/01 00:00 [pmc-release]
AID - JVI.01590-06 [pii]
AID - 1590-06 [pii]
AID - 10.1128/JVI.01590-06 [doi]
PST - ppublish
SO  - J Virol. 2007 Jan;81(1):237-47. doi: 10.1128/JVI.01590-06. Epub 2006 Nov 1.