PMID- 17079940
OWN - NLM
STAT- MEDLINE
DCOM- 20061128
LR  - 20151119
IS  - 1536-4828 (Electronic)
IS  - 0885-3177 (Linking)
VI  - 33
IP  - 4
DP  - 2006 Nov
TI  - Significant increase of serum high-mobility group box chromosomal protein 1 
      levels in patients with severe acute pancreatitis.
PG  - 359-63
AB  - OBJECTIVE: Multiple organ failure because of systemic inflammatory response in 
      the early phase and sepsis in the late phase is the main contributor to high 
      mortality in severe acute pancreatitis (SAP). High-mobility group box chromosomal 
      protein 1 (HMGB1) was recently identified as a potent proinflammatory mediator 
      and increases in various pathological conditions such as sepsis. The aim of this 
      study was to investigate contributions of HMGB1 in SAP. METHODS: We measured 
      serum HMGB1 concentrations by an enzyme-linked immunosorbent assay in 45 patients 
      with SAP at the time of admission. Furthermore, relationship between their serum 
      HMGB1 levels and clinical factors was analyzed. RESULTS: The mean value of serum 
      HMGB1 levels was significantly higher in patients with SAP (5.4 +/- 1.3 ng/mL) 
      than that in healthy volunteers (1.7 +/- 0.3 ng/mL). Serum HMGB1 levels were 
      significantly positively correlated with the Japanese severity score and Glasgow 
      score. Serum HMGB1 levels were significantly positively correlated with lactate 
      dehydrogenase, C-reactive protein, and total bilirubin. The HMGB1 levels were 
      higher in patients with organ dysfunction and infection during the clinical 
      course. The HMGB1 levels in nonsurvivors were higher than those in survivors. 
      Serum HMGB1 levels gradually declined after the admission. CONCLUSIONS: Serum 
      HMGB1 levels were significantly increased in patients with SAP and were 
      correlated with disease severity. These results suggest that HMGB1 may act as a 
      key mediator for inflammation and organ failure in SAP.
FAU - Yasuda, Takeo
AU  - Yasuda T
AD  - Department of Gastroenterological Surgery, Kobe University Graduate School of 
      Medical Sciences, Japan. yasudatk@med.kobe-u.ac.jp
FAU - Ueda, Takashi
AU  - Ueda T
FAU - Takeyama, Yoshifumi
AU  - Takeyama Y
FAU - Shinzeki, Makoto
AU  - Shinzeki M
FAU - Sawa, Hidehiro
AU  - Sawa H
FAU - Nakajima, Takahiro
AU  - Nakajima T
FAU - Ajiki, Tetsuo
AU  - Ajiki T
FAU - Fujino, Yasuhiro
AU  - Fujino Y
FAU - Suzuki, Yasuyuki
AU  - Suzuki Y
FAU - Kuroda, Yoshikazu
AU  - Kuroda Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Pancreas
JT  - Pancreas
JID - 8608542
RN  - 0 (Biomarkers)
RN  - 0 (HMGB1 Protein)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - RFM9X3LJ49 (Bilirubin)
SB  - IM
MH  - Bacterial Infections/blood/complications
MH  - Bilirubin/blood
MH  - Biomarkers/blood
MH  - C-Reactive Protein/metabolism
MH  - Female
MH  - HMGB1 Protein/*blood
MH  - Humans
MH  - L-Lactate Dehydrogenase/blood
MH  - Male
MH  - Middle Aged
MH  - Multiple Organ Failure/blood/etiology
MH  - Pancreatitis/*blood/complications
MH  - Pancreatitis, Acute Necrotizing/blood
MH  - Prognosis
MH  - Severity of Illness Index
MH  - Systemic Inflammatory Response Syndrome/blood/etiology
MH  - Time Factors
EDAT- 2006/11/03 09:00
MHDA- 2006/12/09 09:00
CRDT- 2006/11/03 09:00
PHST- 2006/11/03 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/11/03 09:00 [entrez]
AID - 00006676-200611000-00009 [pii]
AID - 10.1097/01.mpa.0000236741.15477.8b [doi]
PST - ppublish
SO  - Pancreas. 2006 Nov;33(4):359-63. doi: 10.1097/01.mpa.0000236741.15477.8b.