PMID- 17081360
OWN - NLM
STAT- MEDLINE
DCOM- 20070731
LR  - 20111017
IS  - 0253-3758 (Print)
IS  - 0253-3758 (Linking)
VI  - 34
IP  - 7
DP  - 2006 Jul
TI  - [Monocyte chemotactic protein-1 expression in coronary atherosclerosis plaque of 
      sudden coronary death patients].
PG  - 598-601
AB  - OBJECTIVE: To investigate the expression of monocyte chemotactic protein 1 
      (MCP-1) in coronary atherosclerosis plaque of sudden coronary death (SCD) 
      patients and the relationship between MCP-1 expression and SCD. METHODS: Autopsy 
      heart samples (n = 90) collected during 2001 - 2003 were divided to SCD group (n 
      = 36) and 2 control groups: control group I, non-SCD CHD (n = 28), control group 
      II, non-cardiac death (n = 26). The immuno-histochemistry SABC techniques (R, 
      positive MCP-1 cell area/totl area) and computerized images analysis (A) were 
      performed to detect the expression of MCP-1 in different groups. RESULTS: R and A 
      in plaques are significant higher in SCD group than control group I and II 
      (0.1264 +/- 0.013 vs 0.0269 +/- 0.0110 and 0.0267 +/- 0.0100, P = 0.04), (0.4534 
      +/- 0.083 vs 0.2303 +/- 0.040 and 0.2158 +/- 0.0400, P = 0.00), and similar 
      between control group I and control group II. CONCLUSIONS: MCP-1 expression is 
      increased in coronary atherosclerosis plaque of SCD patients.
FAU - Feng, Xiang-ping
AU  - Feng XP
AD  - Faculty of Forensic Medicine, Wenzhou Medical College, Wenzhou 325035, China. 
      fxp@wzmc.net
FAU - Dong, Wen-bin
AU  - Dong WB
FAU - Chen, Xin-shan
AU  - Chen XS
LA  - chi
PT  - Controlled Clinical Trial
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Xin Xue Guan Bing Za Zhi
JT  - Zhonghua xin xue guan bing za zhi
JID - 7910682
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Cadaver
MH  - Chemokine CCL2/*biosynthesis
MH  - Coronary Artery Disease/*metabolism/pathology
MH  - Death, Sudden, Cardiac/*pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Middle Aged
EDAT- 2006/11/04 09:00
MHDA- 2007/08/01 09:00
CRDT- 2006/11/04 09:00
PHST- 2006/11/04 09:00 [pubmed]
PHST- 2007/08/01 09:00 [medline]
PHST- 2006/11/04 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Xin Xue Guan Bing Za Zhi. 2006 Jul;34(7):598-601.