PMID- 17083157
OWN - NLM
STAT- MEDLINE
DCOM- 20061226
LR  - 20061103
IS  - 0033-2240 (Print)
IS  - 0033-2240 (Linking)
VI  - 63
IP  - 4
DP  - 2006
TI  - [Tumor necrosis factor-alpha system in patients with gestational diabetes].
PG  - 173-5
AB  - Tumor necrosis factor-alpha (TNF-alpha) system is potentially involved in the 
      development of insulin resistance during pregnancy. Plasma concentrations of 
      TNF-alpha and its soluble receptors sTNFR-1 and sTNFR-2 were measured in 80 
      patients with gestational diabetes (GDM) (mean age 29.0 +/- 4.9 years) and 30 
      pregnant women with normal glucose tolerance (NGT) (mean age 28.2 +/- 6.0 years). 
      We found that patients with GDM had significantly higher levels of TNF-alpha in 
      comparison to NGT women (1.71+/- 0.92 vs. 1.27 +/- 0.42 pg/ml, p = 0.0175). The 
      differences remained statistically significant after adjusting for BMI (p = 
      0.027). Plasma levels of sTNFR-1 and sTNFR-2 were only slightly higher in 
      patients with GDM (2.83 +/- 0.79 ng/ml vs. 2.55 +/- 0.99 ng/ ml, p = 0.057 and 
      7.46 +/- 2.21 ng/ml vs. 6.83 +/- 1.46 ng/ml, p=0.206, respectively). In the group 
      with GDM TNF-alpha concentrations correlated with sTNFR-1 (r = 0.444, p = 
      0.00008), sTNFR-2 (r = 0.364, p = 0.0016) and with C-peptide concentrations (r = 
      0.318, p = 0.016), whereas in women with NGT - only with triglyceride levels (r = 
      0.50, p = 0.024). Multivariate linear regression analysis revealed that early 
      pregnancy BMI was the most predictive indicator of TNF-alpha concentrations in 
      GDM women (p=0.008). In NTG group triglyceride concentrations, as well as BMI in 
      early pregnancy and at the time of sampling were significant predictors, 
      explaining together 62% of the variance in TNF-alpha concentration. In 
      conclusion, increased TNF-alpha concentrations in women with GDM class G1 
      indicates its contribution to the development of insulin resistance during 
      pregnancy, but the lack of the differences in sTNFR concentrations between the 
      groups studied suggests only moderate TNF-alpha system activation in relatively 
      slim patients treated with diet.
FAU - Kinalski, Maciej
AU  - Kinalski M
AD  - Zaklad Patofizjologii Ciazy, Akademii Medycznej w Bialymstoku.
FAU - Kuzmicki, Mariusz
AU  - Kuzmicki M
FAU - Telejko, Beata
AU  - Telejko B
FAU - Bachorzewski, Rafal
AU  - Bachorzewski R
FAU - Buraczyk, Malgorzata
AU  - Buraczyk M
FAU - Kretowski, Adam
AU  - Kretowski A
FAU - Kinalska, Ida
AU  - Kinalska I
LA  - pol
PT  - English Abstract
PT  - Journal Article
TT  - Aktywnosc ukladu czynnika martwicy guzow alfa (TNF-alpha) u pacjentek z cukrzyca 
      ciazowa.
PL  - Poland
TA  - Przegl Lek
JT  - Przeglad lekarski
JID - 19840720R
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Diabetes, Gestational/*blood
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Pregnancy
MH  - Pregnancy Complications
MH  - Receptors, Tumor Necrosis Factor/*metabolism
MH  - Tumor Necrosis Factor-alpha/*blood
EDAT- 2006/11/04 09:00
MHDA- 2006/12/27 09:00
CRDT- 2006/11/04 09:00
PHST- 2006/11/04 09:00 [pubmed]
PHST- 2006/12/27 09:00 [medline]
PHST- 2006/11/04 09:00 [entrez]
PST - ppublish
SO  - Przegl Lek. 2006;63(4):173-5.