PMID- 17085928
OWN - NLM
STAT- MEDLINE
DCOM- 20070105
LR  - 20190608
IS  - 0019-8366 (Print)
IS  - 0019-8366 (Linking)
VI  - 44
IP  - 4
DP  - 2006 Oct
TI  - Effects of in utero and lactational exposure to di(2-ethylhexyl)phthalate on 
      somatic and physical development in rat offspring.
PG  - 652-60
AB  - Di(2-ethylhexyl)phthalate (DEHP) has been reported to act as an antiandrogen and 
      to affect the reproductive organs and accessory genital glands. Thus, to assess 
      the reproductive toxicity of DEHP it is important to examine both its adverse 
      effects on the development of offspring following maternal exposure and its 
      effects on sexual function and fertility. In the present study, we examined 
      whether in utero and lactational exposure to DEHP affects postnatal somatic 
      growth of offspring in the rat. Pregnant females were orally administered various 
      doses of DEHP (0, 25, 100 or 400 mg/kg body weight/day) from gestational day (GD) 
      6 through postnatal day (PND) 20. There were no significant changes in body 
      weight, body length, tail length, or the weight of individual organs between the 
      control and DEHP-treated groups. Somatic hormonal parameters were the same for 
      all DEHP doses. These findings suggest that in utero and lactational exposure to 
      various concentrations of DEHP has very little effect on postnatal development or 
      endocrine and physical status of male and female rat offspring under the 
      experimental conditions of the present study.
FAU - Kobayashi, Kenichi
AU  - Kobayashi K
AD  - National Institute of Occupational Safety and Health, Nagao, Kawasaki, Japan.
FAU - Miyagawa, Muneyuki
AU  - Miyagawa M
FAU - Wang, Rui-Sheng
AU  - Wang RS
FAU - Suda, Megumi
AU  - Suda M
FAU - Sekiguchi, Soichiro
AU  - Sekiguchi S
FAU - Honma, Takeshi
AU  - Honma T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Ind Health
JT  - Industrial health
JID - 2985065R
RN  - 0 (Hormones)
RN  - C42K0PH13C (Diethylhexyl Phthalate)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Body Weight/drug effects
MH  - Diethylhexyl Phthalate/*toxicity
MH  - Female
MH  - Fetal Development/*drug effects
MH  - Genitalia, Female/drug effects
MH  - Genitalia, Male/drug effects
MH  - Hormones/blood
MH  - Lactation
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Organ Size/drug effects
MH  - Pregnancy
MH  - Rats
MH  - Risk Assessment
MH  - Sex Differentiation/drug effects
MH  - Sexual Maturation/drug effects
EDAT- 2006/11/07 09:00
MHDA- 2007/01/06 09:00
CRDT- 2006/11/07 09:00
PHST- 2006/11/07 09:00 [pubmed]
PHST- 2007/01/06 09:00 [medline]
PHST- 2006/11/07 09:00 [entrez]
AID - JST.JSTAGE/indhealth/44.652 [pii]
AID - 10.2486/indhealth.44.652 [doi]
PST - ppublish
SO  - Ind Health. 2006 Oct;44(4):652-60. doi: 10.2486/indhealth.44.652.