PMID- 17086740
OWN - NLM
STAT- MEDLINE
DCOM- 20070914
LR  - 20161020
IS  - 1001-9294 (Print)
IS  - 1001-9294 (Linking)
VI  - 21
IP  - 3
DP  - 2006 Sep
TI  - Serum concentrations of hyaluronic acid, procollagen type III NH2-terminal 
      peptide, and laminin in patients with chronic congestive heart failure.
PG  - 175-8
AB  - OBJECTIVE: To explore the role of serum fibrotic indices including hyaluronic 
      acid (HA), procollagen type III NH2 -terminal peptide (PCIIIP), and laminin (LN) 
      in assessing the severity of myocardial fibrosis in chronic congestive heart 
      failure (CHF). METHODS: Serum levels of HA, PCIIIP, and LN in 39 patients with 
      CHF [14 with New York Heart Association (NYHA) functional class II, 21 with class 
      III, 4 with class IV] and in 46 patients with NYHA functional class I were 
      assessed by radioimmunoassay. RESULTS: The serum concentrations of HA, PCIIIP, 
      and LN were 359.75 +/- 84.59 microg/L, 77.88 +/- 24.67 microg/L, 86.73 +/- 23.90 
      microg/L in CHF group, and 211.60 +/- 54. 80 microg/L, 64.82 +/- 23.99 microg/L, 
      82.26 +/- 23.98 microg/L in NYHA functional class I group, respectively. The HA 
      level was significantly higher in CHF patients as compared with NYHA functional 
      class I group (P < 0.05). However, no difference was found in the levels of 
      PCIIIP and LN between CHF group and NYHA functional class I group. The serum HA 
      concentration was negatively correlated with left ventricular ejection fraction 
      (r = - 0.71, P < 0.05). CONCLUSION: Serum HA level may act as an indicator for 
      myocardial fibrosis.
FAU - Li, Gang
AU  - Li G
AD  - Division of Cardiology, Department of Geriatrics, the First Affiliated Hospital, 
      Chongqing University of Medical Sciences, Chongqing 400016. harborli@126.com
FAU - Yan, Qing-bo
AU  - Yan QB
FAU - Wei, Liang-ming
AU  - Wei LM
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med Sci J
JT  - Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih
JID - 9112559
RN  - 0 (Biomarkers)
RN  - 0 (Collagen Type III)
RN  - 0 (Laminin)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers/blood
MH  - Collagen Type III/*blood
MH  - Female
MH  - Fibrosis/blood
MH  - Heart Failure/*blood
MH  - Humans
MH  - Hyaluronic Acid/*blood
MH  - Laminin/*blood
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Severity of Illness Index
EDAT- 2006/11/08 09:00
MHDA- 2007/09/15 09:00
CRDT- 2006/11/08 09:00
PHST- 2006/11/08 09:00 [pubmed]
PHST- 2007/09/15 09:00 [medline]
PHST- 2006/11/08 09:00 [entrez]
PST - ppublish
SO  - Chin Med Sci J. 2006 Sep;21(3):175-8.