PMID- 17088035
OWN - NLM
STAT- MEDLINE
DCOM- 20070420
LR  - 20070115
IS  - 0378-8741 (Print)
IS  - 0378-8741 (Linking)
VI  - 109
IP  - 3
DP  - 2007 Feb 12
TI  - Postnatal development and reproductive performance of F1 progeny exposed in utero 
      to an ayurvedic contraceptive: Pippaliyadi yoga.
PG  - 406-11
AB  - Pippaliyadi yoga or pippaliyadi vati is an ayurvedic contraceptive used in India 
      since ancient times. It is a combination of powdered fruit berries of Embelia 
      ribes Burm.f. (Myrsinaceae), Piper longum L. (Piperaceae) and borax in equal 
      proportion. Though the contraceptive potential is known since ancient times, no 
      systematic developmental toxicity studies have been carried out. The present 
      study was carried out to evaluate the postnatal developmental toxicity and the 
      reproductive performance of the progeny exposed in utero to pippaliyadi. 
      Pippaliyadi yoga was obtained from National Institute for Pharmaceutical 
      Education and Research (NIPER), India and the developmental toxicity was studied 
      by administering three doses, viz. 140, 300 and 700 mg/(kg day) to gravid females 
      from day 6 to day 16 of gestation. Pippaliyadi did not have any adverse 
      developmental effects with low doses, however, with the five times higher dose, a 
      decrease in body weight of the pups was observed. The reproductive performance of 
      the progeny born to mothers treated with pippaliyadi was not significantly 
      affected. The present study suggests that in utero exposure to pippaliyadi does 
      not have any adverse effect on the postnatal development and reproductive 
      performance of the F(1) progeny.
FAU - Balasinor, Nafisa
AU  - Balasinor N
AD  - National Institute for Research in Reproductive Health (ICMR), J.M. Street, 
      Parel, Mumbai 400012, Maharashtra, India. nafisbala@hotmail.com
FAU - Bhan, Ashima
AU  - Bhan A
FAU - Paradkar, Niraja S
AU  - Paradkar NS
FAU - Shaikh, Arifa
AU  - Shaikh A
FAU - Nandedkar, Tarala D
AU  - Nandedkar TD
FAU - Bhutani, K K
AU  - Bhutani KK
FAU - Roy-Chaudhury, Mandakini
AU  - Roy-Chaudhury M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060815
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Contraceptive Agents, Female)
RN  - 0 (Plant Preparations)
SB  - IM
MH  - Animals
MH  - Contraceptive Agents, Female/*pharmacology
MH  - *Embelia
MH  - Female
MH  - Fruit/chemistry
MH  - Hair/drug effects/growth & development
MH  - Male
MH  - Maternal-Fetal Exchange
MH  - Medicine, Ayurvedic
MH  - *Piper
MH  - Plant Preparations/*pharmacology
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reproduction/drug effects
MH  - Vagina/drug effects/growth & development
EDAT- 2006/11/08 09:00
MHDA- 2007/04/21 09:00
CRDT- 2006/11/08 09:00
PHST- 2006/02/28 00:00 [received]
PHST- 2006/08/01 00:00 [revised]
PHST- 2006/08/11 00:00 [accepted]
PHST- 2006/11/08 09:00 [pubmed]
PHST- 2007/04/21 09:00 [medline]
PHST- 2006/11/08 09:00 [entrez]
AID - S0378-8741(06)00404-1 [pii]
AID - 10.1016/j.jep.2006.08.007 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2007 Feb 12;109(3):406-11. doi: 10.1016/j.jep.2006.08.007. Epub 
      2006 Aug 15.