PMID- 17089044
OWN - NLM
STAT- MEDLINE
DCOM- 20061228
LR  - 20220318
IS  - 1021-335X (Print)
IS  - 1021-335X (Linking)
VI  - 16
IP  - 6
DP  - 2006 Dec
TI  - Significance of the serum brain-derived neurotrophic factor and platelets in 
      hepatocellular carcinoma.
PG  - 1237-43
AB  - The present study investigated the significance of the serum brain-derived 
      neurotrophic factor (BDNF) and platelets in relation to the clinicopathological 
      features of hepatocellular carcinoma (HCC) patients. Localization of the BDNF 
      expression in human HCC tissues was performed by immunohistochemistry. The 
      measurement of soluble BDNF in the serum was performed by enzyme-linked 
      immunosorbent assay. BDNF was expressed in the cytoplasm of the tumor cells. A 
      positive correlation between the tissue and serum levels of BDNF was identified 
      in the HCC patients. The serum levels of BDNF were positively correlated with the 
      platelet counts in the HCC patients. A higher level of serum BDNF was 
      significantly correlated with a tumor size >5 cm, poorly differentiated HCC, the 
      presence of microsatellite tumor nodules, and the absence of cirrhosis in the 
      non-tumorous tissues. A higher level of the serum BDNF/platelet ratio was 
      associated with a poorer disease-free survival after hepatic resection. This 
      study suggested that the tumor cell was a source of serum BDNF in HCC. A higher 
      serum BDNF level was associated with a more advanced tumor status in the HCC 
      patients. The interaction between serum BDNF and platelets might play an 
      important role in HCC tumor progression.
FAU - Yang, Zhen Fan
AU  - Yang ZF
AD  - Centre for the Study of Lvier Disease and Department of Surgery, The University 
      of Hong Kong, Hong Kong, P.R. China. zfyang@hkucc.hku.hk
FAU - Ho, David W
AU  - Ho DW
FAU - Lau, Chi Keung
AU  - Lau CK
FAU - Tam, Ka Ho
AU  - Tam KH
FAU - Lam, Chi Tat
AU  - Lam CT
FAU - Yu, Wan Ching
AU  - Yu WC
FAU - Poon, Ronnie T P
AU  - Poon RT
FAU - Fan, Sheung Tat
AU  - Fan ST
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Greece
TA  - Oncol Rep
JT  - Oncology reports
JID - 9422756
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Blood Platelets/physiology
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Carcinoma, Hepatocellular/*metabolism/mortality/*pathology
MH  - Disease-Free Survival
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Liver Neoplasms/*metabolism/mortality/*pathology
MH  - Male
MH  - Middle Aged
MH  - *Platelet Count
MH  - Prognosis
EDAT- 2006/11/08 09:00
MHDA- 2006/12/29 09:00
CRDT- 2006/11/08 09:00
PHST- 2006/11/08 09:00 [pubmed]
PHST- 2006/12/29 09:00 [medline]
PHST- 2006/11/08 09:00 [entrez]
PST - ppublish
SO  - Oncol Rep. 2006 Dec;16(6):1237-43.