PMID- 17089884
OWN - NLM
STAT- MEDLINE
DCOM- 20061212
LR  - 20190622
IS  - 0065-2598 (Print)
IS  - 0065-2598 (Linking)
VI  - 588
DP  - 2006
TI  - Hypoxic preconditioning and erythropoietin protect retinal neurons from 
      degeneration.
PG  - 119-31
AB  - Reduced tissue oxygenation stabilizes the alpha-subunit of the transcription 
      factor hypoxia-inducible factor-1 (HIF-1). This leads to the induction of a 
      number of hypoxia responsive genes. One of the best known HIF-1 targets is 
      erythropoietin that exerts neuroprotective effects on ischemia-related injury in 
      the brain. Thus, pre-exposure to low environmental oxygen concentrations might be 
      exploited as a preconditioning procedure to protect tissues against a variety of 
      harmful conditions. We present recent work on neuroprotection of retinal 
      photoreceptors induced by hypoxic preconditioning or by systemically elevated 
      levels of Epo in mouse plasma.
FAU - Grimm, Christian
AU  - Grimm C
AD  - Laboratory of Retinal Cell Biology, Eye Hospital Zurich and Center for 
      Integrative Human Physiology, Zurich, Switzerland.
FAU - Wenzel, A
AU  - Wenzel A
FAU - Acar, N
AU  - Acar N
FAU - Keller, S
AU  - Keller S
FAU - Seeliger, M
AU  - Seeliger M
FAU - Gassmann, Max
AU  - Gassmann M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Adv Exp Med Biol
JT  - Advances in experimental medicine and biology
JID - 0121103
RN  - 11096-26-7 (Erythropoietin)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Brain/metabolism
MH  - Erythropoietin/blood/metabolism/*physiology
MH  - *Hypoxia/metabolism
MH  - Ischemia/pathology
MH  - Ischemic Preconditioning
MH  - Mice
MH  - Mice, Transgenic
MH  - Neurons/*metabolism
MH  - Oxygen/metabolism
MH  - Retina/metabolism
MH  - *Retinal Degeneration
MH  - Retinal Ganglion Cells/*metabolism
MH  - Time Factors
MH  - Up-Regulation
RF  - 69
EDAT- 2006/11/09 09:00
MHDA- 2006/12/13 09:00
CRDT- 2006/11/09 09:00
PHST- 2006/11/09 09:00 [pubmed]
PHST- 2006/12/13 09:00 [medline]
PHST- 2006/11/09 09:00 [entrez]
AID - 10.1007/978-0-387-34817-9_11 [doi]
PST - ppublish
SO  - Adv Exp Med Biol. 2006;588:119-31. doi: 10.1007/978-0-387-34817-9_11.