PMID- 17091256
OWN - NLM
STAT- MEDLINE
DCOM- 20070720
LR  - 20181113
IS  - 0945-6317 (Print)
IS  - 0945-6317 (Linking)
VI  - 449
IP  - 6
DP  - 2006 Dec
TI  - Expression of p16 in sinonasal malignant melanoma.
PG  - 667-72
AB  - The aim of this study was to investigate the expression of p16 in relation with 
      the histopathologic features and the clinical course in patients with sinonasal 
      melanoma. Thirty-seven sinonasal melanomas were immunostained for p16. Seventeen 
      tumours were investigated for loss of the 9p21 region using interphase 
      fluorescence in situ hybridization (FISH). Twenty-seven melanomas (72.9%) showed 
      loss of p16 expression. All cases with spindle or mixed cytology showed loss of 
      p16, whereas this was present in 50% of epithelioid tumours (p=0.01). Loss of p16 
      expression was more frequently seen in melanomas with alveolar architecture 
      (87.5%) than in tumours with diffuse architecture (68.9%) (p=0.4). There was no 
      correlation between p16 expression and presence of lymph node or distant 
      metastases (p=0.57 and 0.24, respectively). In addition, p16 status did not 
      influence overall survival (p=0.2). The FISH results were in good agreement with 
      immunohistochemistry: 11 tumours out of 17 showed deletion of the 9p21 region and 
      10 of these showed loss of protein expression. Loss of p16 expression is a 
      frequent event in sinonasal melanoma and it is mainly related to deletion of 9p21 
      region. At variance from cutaneous melanoma, loss of p16 is not correlated with 
      the prognosis of patients affected by sinonasal melanoma.
FAU - Franchi, Alessandro
AU  - Franchi A
AD  - Department of Human Pathology and Oncology, University of Florence, Viale G.B. 
      Morgagni 85, 50134 Florence, Italy. Franchi@unifi.it
FAU - Alos, Llucia
AU  - Alos L
FAU - Gale, Nina
AU  - Gale N
FAU - Massi, Daniela
AU  - Massi D
FAU - Paglierani, Milena
AU  - Paglierani M
FAU - Santucci, Marco
AU  - Santucci M
FAU - Zidar, Nina
AU  - Zidar N
FAU - Cardesa, Antonio
AU  - Cardesa A
LA  - eng
PT  - Journal Article
DEP - 20061108
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
RN  - 0 (Cyclin-Dependent Kinase Inhibitor p16)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Cyclin-Dependent Kinase Inhibitor p16/*analysis
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Melanoma/*chemistry/pathology
MH  - Middle Aged
MH  - Paranasal Sinus Neoplasms/*chemistry/pathology
EDAT- 2006/11/09 09:00
MHDA- 2007/07/21 09:00
CRDT- 2006/11/09 09:00
PHST- 2006/05/18 00:00 [received]
PHST- 2006/07/31 00:00 [accepted]
PHST- 2006/11/09 09:00 [pubmed]
PHST- 2007/07/21 09:00 [medline]
PHST- 2006/11/09 09:00 [entrez]
AID - 10.1007/s00428-006-0288-0 [doi]
PST - ppublish
SO  - Virchows Arch. 2006 Dec;449(6):667-72. doi: 10.1007/s00428-006-0288-0. Epub 2006 
      Nov 8.