PMID- 17095017 OWN - NLM STAT- MEDLINE DCOM- 20071213 LR - 20220310 IS - 0022-3956 (Print) IS - 0022-3956 (Linking) VI - 41 IP - 12 DP - 2007 Dec TI - Serum BDNF levels and weight gain in schizophrenic patients on long-term treatment with antipsychotics. PG - 997-1004 AB - Several lines of evidence suggest that central brain-derived neurotrophic factor (BDNF) modulates food intake, metabolism, and increases in body weight. Reports have also shown that serum BDNF is altered in schizophrenic patients treated with antipsychotics. This study aimed to determine if there was a relationship between BDNF and antipsychotic-induced weight gain in patients with chronic schizophrenia. Serum BDNF was measured in 124 schizophrenia patients chronically treated with clozapine (n=57), risperidone (n=23) or typical antipsychotics (n=44) and 50 healthy control subjects. To further assess group differences in serum BDNF, additional analyses were performed in a subset of patients and controls individually matched for body mass index (BMI). BDNF levels were lower in patients with schizophrenia than normal controls. However, this difference was not present when controlling for current BMI. In the individually BMI-matched sample, no differences in serum BDNF levels were observed in schizophrenic patients compared to BMI-matched healthy controls. BDNF levels negatively correlated with BMI gain in female but not in male patients when gender was considered. Antipsychotic class exerted differential effects over BDNF levels and BMI gain. Our findings suggest that decreased BDNF levels may be associated with weight gain in female schizophrenic patients on long-term antipsychotic treatment. FAU - Zhang, Xiang Yang AU - Zhang XY AD - Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, VA Medical Center, Houston, TX 77030, USA. xyzhang@bcm.edu FAU - Tan, Yun Long AU - Tan YL FAU - Zhou, Dong Feng AU - Zhou DF FAU - Cao, Lian Yuan AU - Cao LY FAU - Wu, Gui Ying AU - Wu GY FAU - Xu, Qi AU - Xu Q FAU - Shen, Yan AU - Shen Y FAU - Haile, Colin N AU - Haile CN FAU - Kosten, Therese A AU - Kosten TA FAU - Kosten, Thomas R AU - Kosten TR LA - eng GR - K05-DA0454/DA/NIDA NIH HHS/United States GR - P50-DA18827/DA/NIDA NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20061113 PL - England TA - J Psychiatr Res JT - Journal of psychiatric research JID - 0376331 RN - 0 (Antipsychotic Agents) RN - 0 (Brain-Derived Neurotrophic Factor) RN - J60AR2IKIC (Clozapine) RN - L6UH7ZF8HC (Risperidone) SB - IM MH - Antipsychotic Agents/*adverse effects/therapeutic use MH - Brain-Derived Neurotrophic Factor/*blood MH - Chronic Disease MH - Clozapine/therapeutic use MH - Female MH - Humans MH - Male MH - Middle Aged MH - Risperidone/therapeutic use MH - Schizophrenia/*drug therapy/physiopathology MH - Serum MH - *Weight Gain EDAT- 2006/11/11 09:00 MHDA- 2007/12/14 09:00 CRDT- 2006/11/11 09:00 PHST- 2006/04/04 00:00 [received] PHST- 2006/08/17 00:00 [revised] PHST- 2006/08/23 00:00 [accepted] PHST- 2006/11/11 09:00 [pubmed] PHST- 2007/12/14 09:00 [medline] PHST- 2006/11/11 09:00 [entrez] AID - S0022-3956(06)00176-2 [pii] AID - 10.1016/j.jpsychires.2006.08.007 [doi] PST - ppublish SO - J Psychiatr Res. 2007 Dec;41(12):997-1004. doi: 10.1016/j.jpsychires.2006.08.007. Epub 2006 Nov 13.