PMID- 17095929
OWN - NLM
STAT- MEDLINE
DCOM- 20070130
LR  - 20211203
IS  - 0195-9131 (Print)
IS  - 0195-9131 (Linking)
VI  - 38
IP  - 11
DP  - 2006 Nov
TI  - mTOR signaling and the molecular adaptation to resistance exercise.
PG  - 1950-7
AB  - Skeletal muscle size is dynamic and responsive to extracellular signals such as 
      mechanical load, neural activity, hormones, growth factors, and cytokines. The 
      signaling pathways responsible for regulating cell size in adult skeletal muscle 
      under growth and atrophy conditions are poorly understood. However, recent 
      evidence suggests a role for the PI3K/Akt/mTOR pathway. Protein translation is 
      regulated through the phosphorylation of initiation factors that are controlled 
      by signaling pathways downstream of PI3K/Akt. Recent work in mammals has 
      suggested that activation of Akt/PKB, a Ser-Thr phosphatidylinositol-regulated 
      kinase, and its downstream targets, glycogen synthase kinase-3 (GSK3) and the 
      mammalian target of rapamycin (mTOR), may be critical regulators of postnatal 
      cell size in multiple organ systems, including skeletal muscle. This paper will 
      review some of the recent data that demonstrate the critical role of Akt/mTOR 
      signaling in the regulation of postnatal muscle size, especially under conditions 
      of increased external loading.
FAU - Bodine, Sue C
AU  - Bodine SC
AD  - Section of Neurobiology, Physiology & Behavior, University of California Davis, 
      Davis, CA 95616, USA. scbodine@ucdavis.edu
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Med Sci Sports Exerc
JT  - Medicine and science in sports and exercise
JID - 8005433
RN  - 0 (Adrenergic beta-Agonists)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
RN  - XTZ6AXU7KN (Clenbuterol)
SB  - IM
MH  - *Adaptation, Physiological
MH  - Adrenergic beta-Agonists/pharmacology
MH  - Animals
MH  - Clenbuterol/pharmacology
MH  - Exercise/*physiology
MH  - Humans
MH  - Muscle, Skeletal/drug effects/growth & development
MH  - Physical Endurance/*physiology
MH  - Protein Kinases/*metabolism
MH  - Protein Transport/physiology
MH  - Signal Transduction/*physiology
MH  - TOR Serine-Threonine Kinases
RF  - 52
EDAT- 2006/11/11 09:00
MHDA- 2007/01/31 09:00
CRDT- 2006/11/11 09:00
PHST- 2006/11/11 09:00 [pubmed]
PHST- 2007/01/31 09:00 [medline]
PHST- 2006/11/11 09:00 [entrez]
AID - 00005768-200611000-00011 [pii]
AID - 10.1249/01.mss.0000233797.24035.35 [doi]
PST - ppublish
SO  - Med Sci Sports Exerc. 2006 Nov;38(11):1950-7. doi: 
      10.1249/01.mss.0000233797.24035.35.