PMID- 17096834
OWN - NLM
STAT- MEDLINE
DCOM- 20061121
LR  - 20181113
IS  - 1471-2350 (Electronic)
IS  - 1471-2350 (Linking)
VI  - 7
DP  - 2006 Nov 10
TI  - No association between polymorphisms in the BDNF gene and age at onset in 
      Huntington disease.
PG  - 79
AB  - BACKGROUND: Recent evidence suggests that brain-derived neurotrophic factor 
      (BDNF) is an attractive candidate for modifying age at onset (AO) in Huntington 
      disease (HD). In particular, the functional Val66Met polymorphism appeared to 
      exert a significant effect. Here we evaluate BDNF variability with respect to AO 
      of HD using markers that represent the entire locus. METHODS: Five selected 
      tagging polymorphisms were genotyped across a 65 kb region comprising the BDNF 
      gene in a well established cohort of 250 unrelated German HD patients. RESULTS: 
      Addition of BDNF genotype variations or one of the marker haplotypes to the 
      effect of CAG repeat lengths did not affect the variance of the AO. CONCLUSION: 
      We were unable to verify a recently reported association between the functional 
      Val66Met polymorphism in the BDNF gene and AO in HD. From our findings, we 
      conclude that neither sequence variations in nor near the gene contribute 
      significantly to the variance of AO.
FAU - Mai, Maren
AU  - Mai M
AD  - Department of Human Genetics, Ruhr-University, 44780 Bochum, Germany. 
      Maren-Mai@gmx.de
FAU - Akkad, Amer D
AU  - Akkad AD
FAU - Wieczorek, Stefan
AU  - Wieczorek S
FAU - Saft, Carsten
AU  - Saft C
FAU - Andrich, Jurgen
AU  - Andrich J
FAU - Kraus, Peter H
AU  - Kraus PH
FAU - Epplen, Jorg T
AU  - Epplen JT
FAU - Arning, Larissa
AU  - Arning L
LA  - eng
PT  - Journal Article
DEP - 20061110
PL  - England
TA  - BMC Med Genet
JT  - BMC medical genetics
JID - 100968552
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Codon)
RN  - AE28F7PNPL (Methionine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Age of Onset
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Codon
MH  - Humans
MH  - Huntington Disease/*genetics
MH  - Methionine/genetics
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - Trinucleotide Repeats
MH  - Valine/genetics
PMC - PMC1637098
EDAT- 2006/11/14 09:00
MHDA- 2006/12/09 09:00
PMCR- 2006/11/10
CRDT- 2006/11/14 09:00
PHST- 2006/08/08 00:00 [received]
PHST- 2006/11/10 00:00 [accepted]
PHST- 2006/11/14 09:00 [pubmed]
PHST- 2006/12/09 09:00 [medline]
PHST- 2006/11/14 09:00 [entrez]
PHST- 2006/11/10 00:00 [pmc-release]
AID - 1471-2350-7-79 [pii]
AID - 10.1186/1471-2350-7-79 [doi]
PST - epublish
SO  - BMC Med Genet. 2006 Nov 10;7:79. doi: 10.1186/1471-2350-7-79.