PMID- 17096853
OWN - NLM
STAT- MEDLINE
DCOM- 20061215
LR  - 20220317
IS  - 1477-7827 (Electronic)
IS  - 1477-7827 (Linking)
VI  - 4
DP  - 2006 Nov 10
TI  - Effects of nerve growth factor (NGF) on blood vessels area and expression of the 
      angiogenic factors VEGF and TGFbeta1 in the rat ovary.
PG  - 57
AB  - BACKGROUND: Angiogenesis is a crucial process in follicular development and 
      luteogenesis. The nerve growth factor (NGF) promotes angiogenesis in various 
      tissues. An impaired production of this neurotrophin has been associated with 
      delayed wound healing. A variety of ovarian functions are regulated by NGF, but 
      its effects on ovarian angiogenesis remain unknown. The aim of this study was to 
      elucidate if NGF modulates 1) the amount of follicular blood vessels and 2) 
      ovarian expression of two angiogenic factors: vascular endothelial growth factor 
      (VEGF) and transforming growth factor beta 1 (TGFbeta1), in the rat ovary. 
      RESULTS: In cultured neonatal rat ovaries, NGF increased VEGF mRNA and protein 
      levels, whereas TGFbeta1 expression did not change. Sectioning of the superior 
      ovarian nerve, which increases ovarian NGF protein content, augmented VEGF 
      immunoreactivity and the area of capillary vessels in ovaries of prepubertal rats 
      compared to control ovaries. CONCLUSION: Results indicate that NGF may be 
      important in the maintenance of the follicular and luteal vasculature in adult 
      rodents, either indirectly, by increasing the expression of VEGF in the ovary, or 
      directly via promoting the proliferation of vascular cells. This data suggests 
      that a disruption on NGF regulation could be a component in ovarian disorders 
      related with impaired angiogenesis.
FAU - Julio-Pieper, Marcela
AU  - Julio-Pieper M
AD  - Laboratory of Endocrinology and Reproductive Biology, Hospital Clinico 
      Universidad de Chile, Santiago, Chile. mjulio@ciq.uchile.cl 
      <mjulio@ciq.uchile.cl>
FAU - Lara, Hernan E
AU  - Lara HE
FAU - Bravo, Javier A
AU  - Bravo JA
FAU - Romero, Carmen
AU  - Romero C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061110
PL  - England
TA  - Reprod Biol Endocrinol
JT  - Reproductive biology and endocrinology : RB&E
JID - 101153627
RN  - 0 (Tgfb1 protein, rat)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (vascular endothelial growth factor A, rat)
RN  - 9061-61-4 (Nerve Growth Factor)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Blood Vessels/drug effects
MH  - Denervation
MH  - Female
MH  - Gene Expression Regulation/drug effects
MH  - Immunohistochemistry
MH  - *Neovascularization, Physiologic
MH  - Nerve Growth Factor/*pharmacology
MH  - Ovary/*blood supply/drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Transforming Growth Factor beta1/genetics/*metabolism
MH  - Vascular Endothelial Growth Factor A/genetics/*metabolism
PMC - PMC1665630
EDAT- 2006/11/14 09:00
MHDA- 2006/12/16 09:00
PMCR- 2006/11/10
CRDT- 2006/11/14 09:00
PHST- 2006/09/26 00:00 [received]
PHST- 2006/11/10 00:00 [accepted]
PHST- 2006/11/14 09:00 [pubmed]
PHST- 2006/12/16 09:00 [medline]
PHST- 2006/11/14 09:00 [entrez]
PHST- 2006/11/10 00:00 [pmc-release]
AID - 1477-7827-4-57 [pii]
AID - 10.1186/1477-7827-4-57 [doi]
PST - epublish
SO  - Reprod Biol Endocrinol. 2006 Nov 10;4:57. doi: 10.1186/1477-7827-4-57.