PMID- 17097239
OWN - NLM
STAT- MEDLINE
DCOM- 20070328
LR  - 20061212
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 144
IP  - 2
DP  - 2007 Jan 19
TI  - Short-term exposure to an enriched environment enhances dendritic branching but 
      not brain-derived neurotrophic factor expression in the hippocampus of rats with 
      ventral subicular lesions.
PG  - 412-23
AB  - Environmental enrichment promotes structural and behavioral plasticity in the 
      adult brain. We have evaluated the efficacy of enriched environment on the 
      dendritic morphology and brain-derived neurotrophic factor (BDNF) expression in 
      the hippocampus of ventral subicular-lesioned rats. Bilateral ventral subicular 
      lesion has significantly reduced the dendritic architecture and spine density of 
      hippocampal pyramidal neurons. The lesioned rats exposed to enriched housing for 
      10 days showed a significant degree of morphological plasticity in terms of 
      enhanced dendritic branching and spine density. However, the BDNF expression in 
      the hippocampus remained unchanged following subicular lesion and following 
      environmental enrichment. We suggest the participation of other neurotrophic 
      factors in mediating the synaptic plasticity events following exposure to 
      environmental enrichment in ventral subicular-lesioned rats.
FAU - Bindu, B
AU  - Bindu B
AD  - Department of Neurophysiology, National Institute of Mental Health and Neuro 
      Sciences, Hosur Road, Bangalore, India.
FAU - Alladi, P A
AU  - Alladi PA
FAU - Mansooralikhan, B M
AU  - Mansooralikhan BM
FAU - Srikumar, B N
AU  - Srikumar BN
FAU - Raju, T R
AU  - Raju TR
FAU - Kutty, B M
AU  - Kutty BM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061109
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Animals
MH  - Blotting, Western/methods
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Dendrites/*pathology/ultrastructure
MH  - *Environment
MH  - Gene Expression Regulation/*physiology
MH  - *Hippocampus/injuries/metabolism/pathology
MH  - Immunohistochemistry/methods
MH  - Male
MH  - Pyramidal Cells/metabolism/ultrastructure
MH  - Rats
MH  - Rats, Wistar
MH  - Silver Staining/methods
EDAT- 2006/11/14 09:00
MHDA- 2007/03/29 09:00
CRDT- 2006/11/14 09:00
PHST- 2006/04/26 00:00 [received]
PHST- 2006/09/18 00:00 [revised]
PHST- 2006/09/20 00:00 [accepted]
PHST- 2006/11/14 09:00 [pubmed]
PHST- 2007/03/29 09:00 [medline]
PHST- 2006/11/14 09:00 [entrez]
AID - S0306-4522(06)01299-1 [pii]
AID - 10.1016/j.neuroscience.2006.09.057 [doi]
PST - ppublish
SO  - Neuroscience. 2007 Jan 19;144(2):412-23. doi: 10.1016/j.neuroscience.2006.09.057. 
      Epub 2006 Nov 9.