PMID- 17097266
OWN - NLM
STAT- MEDLINE
DCOM- 20070319
LR  - 20240318
IS  - 0891-0618 (Print)
IS  - 1873-6300 (Electronic)
IS  - 0891-0618 (Linking)
VI  - 32
IP  - 2-4
DP  - 2006 Dec
TI  - Distribution of NMDA receptor subunit NR1 in arctic ground squirrel central 
      nervous system.
PG  - 196-207
AB  - Hibernation is a natural model of neuroprotection and adult synaptic plasticity. 
      NMDA receptors (NMDAR), which play key roles in excitotoxicity and synaptic 
      plasticity, have not been characterized in a hibernating species. Tolerance to 
      excitotoxicity and cognitive enhancement in Arctic ground squirrels (AGS, 
      Spermophilus parryii) suggests that NMDAR expression may decrease in hibernation 
      and increase upon arousal. NMDAR consist of at least one NMDAR1 (NR1) subunit, 
      which is required for receptor function. Localization of NR1 reflects 
      localization of the majority, if not all, NMDAR complexes. The purpose of this 
      study, therefore, was to characterize the distribution of NR1 subunits in AGS 
      central nervous system using immunohistochemistry. In addition, we compare NR1 
      expression in hippocampus of hibernating AGS (hAGS) and inter-bout euthermic AGS 
      (ibeAGS) and assess changes in cell somata size using NR1 stained sections in 
      three hippocampal sub-regions (CA1, CA3, and dentate gyrus). For the first time, 
      we report that immunoreactivity of anti-NR1 is widely distributed throughout the 
      central nervous system in AGS and is similar to other species. No differences 
      exist in the expression and distribution of NR1 in hAGS and ibeAGS. However, we 
      report a significant decrease in size of hippocampal CA1 and dentate gyrus 
      NR1-expressing neuronal somata during hibernation torpor.
FAU - Zhao, Huiwen W
AU  - Zhao HW
AD  - Alaskan Basic Neuroscience Program, Institute of Arctic Biology, University of 
      Alaska, Fairbanks, AK 99775, USA. huzhao@ucsd.edu
FAU - Christian, Sherri L
AU  - Christian SL
FAU - Castillo, Marina R
AU  - Castillo MR
FAU - Bult-Ito, Abel
AU  - Bult-Ito A
FAU - Drew, Kelly L
AU  - Drew KL
LA  - eng
GR  - U54 NS041069/NS/NINDS NIH HHS/United States
GR  - U54-NS 41069/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20061109
PL  - Netherlands
TA  - J Chem Neuroanat
JT  - Journal of chemical neuroanatomy
JID - 8902615
RN  - 0 (NR1 NMDA receptor)
RN  - 0 (Neurotoxins)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 3KX376GY7L (Glutamic Acid)
SB  - IM
MH  - Animals
MH  - Body Temperature/physiology
MH  - Brain Mapping
MH  - Cell Size
MH  - Central Nervous System/anatomy & histology/*metabolism
MH  - Female
MH  - Glutamic Acid/*metabolism
MH  - Hibernation/*physiology
MH  - Hippocampus/anatomy & histology/metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - Neurons/cytology/metabolism
MH  - Neurotoxins/metabolism
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
MH  - Sciuridae/anatomy & histology/*metabolism
MH  - Synaptic Transmission/*physiology
PMC - PMC3796384
MID - NIHMS451076
EDAT- 2006/11/14 09:00
MHDA- 2007/03/21 09:00
PMCR- 2013/10/14
CRDT- 2006/11/14 09:00
PHST- 2006/04/03 00:00 [received]
PHST- 2006/09/13 00:00 [revised]
PHST- 2006/09/13 00:00 [accepted]
PHST- 2006/11/14 09:00 [pubmed]
PHST- 2007/03/21 09:00 [medline]
PHST- 2006/11/14 09:00 [entrez]
PHST- 2013/10/14 00:00 [pmc-release]
AID - S0891-0618(06)00075-5 [pii]
AID - 10.1016/j.jchemneu.2006.09.002 [doi]
PST - ppublish
SO  - J Chem Neuroanat. 2006 Dec;32(2-4):196-207. doi: 10.1016/j.jchemneu.2006.09.002. 
      Epub 2006 Nov 9.