PMID- 17097765
OWN - NLM
STAT- MEDLINE
DCOM- 20071206
LR  - 20061120
IS  - 0196-9781 (Print)
IS  - 0196-9781 (Linking)
VI  - 27
IP  - 12
DP  - 2006 Dec
TI  - Interleukin-1 beta-induced anorexia is reversed by ghrelin.
PG  - 3220-5
AB  - Interleukins, in particular interleukin-1beta (IL-1beta), reduce food intake 
      after peripheral and central administration, which suggests that they contribute 
      to anorexia during various infectious, neoplastic, and autoimmune diseases. On 
      the other hand, ghrelin stimulates food intake by acting on the central nervous 
      system (CNS) and is considered an important regulator of food intake in both 
      rodents and humans. In the present study, we investigated if ghrelin could 
      reverse IL-1beta-induced anorexia. Intracerebroventricular (i.c.v.) injection of 
      15, 30 or 45 ng/microl of IL-1beta caused significant suppression of food intake 
      in 20 h fasting animals. This effect lasted for a 24h period. Ghrelin (0.15 nmol 
      or 1.5 nmol/microl) produced a significant increase in cumulative food intake in 
      normally fed animals. However, it did not alter food intake in 20 h fasting 
      animals. Central administration of ghrelin reduced the anorexic effect of 
      IL-1beta (15 ng/microl). The effect was observed 30 min after injection and 
      lasted for the next 24h. This study provides evidence that ghrelin is an 
      orexigenic peptide capable of antagonizing IL-1beta-induced anorexia.
FAU - Gonzalez, Patricia Veronica
AU  - Gonzalez PV
AD  - Departamento de Farmacologia, Facultad de Ciencias Quimicas, Ciudad 
      Universitaria, Universidad Nacional de Cordoba, 5000 Cordoba, Argentina.
FAU - Cragnolini, Andrea Beatriz
AU  - Cragnolini AB
FAU - Schioth, Helgi Birgir
AU  - Schioth HB
FAU - Scimonelli, Teresa Nieves
AU  - Scimonelli TN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Peptides
JT  - Peptides
JID - 8008690
RN  - 0 (Ghrelin)
RN  - 0 (Interleukin-1beta)
SB  - IM
MH  - Animals
MH  - Anorexia/*etiology/*prevention & control
MH  - Ghrelin/*physiology
MH  - Injections, Intraventricular
MH  - Interleukin-1beta/administration & dosage/*physiology
MH  - Male
MH  - Rats
MH  - Rats, Wistar
EDAT- 2006/11/14 09:00
MHDA- 2007/12/07 09:00
CRDT- 2006/11/14 09:00
PHST- 2006/06/12 00:00 [received]
PHST- 2006/09/20 00:00 [revised]
PHST- 2006/09/25 00:00 [accepted]
PHST- 2006/11/14 09:00 [pubmed]
PHST- 2007/12/07 09:00 [medline]
PHST- 2006/11/14 09:00 [entrez]
AID - S0196-9781(06)00430-X [pii]
AID - 10.1016/j.peptides.2006.09.008 [doi]
PST - ppublish
SO  - Peptides. 2006 Dec;27(12):3220-5. doi: 10.1016/j.peptides.2006.09.008.