PMID- 17098333
OWN - NLM
STAT- MEDLINE
DCOM- 20080327
LR  - 20220311
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 29
IP  - 3
DP  - 2008 Mar
TI  - Role of 5HT 2A and 5HT 2C polymorphisms in behavioural and psychological symptoms 
      of Alzheimer's disease.
PG  - 341-7
AB  - OBJECTIVE: Alzheimer's disease (AD) patients suffer from behavioural and 
      psychological symptoms of dementia (BPSD). A genetic component to BPSD 
      development in AD has been demonstrated. Polymorphisms within serotonin receptors 
      5HT(2A) and 5HT(2C) have been previously investigated in a few interesting 
      studies reviewed here, however, their role remains unclear. METHODS: Our large 
      cohort of 394 patients had longitudinal information on the BPSD (Neuropsychiatric 
      Inventory), which was used to dichotomise patients into whether they had ever 
      suffered from a given symptom within the study period and give each patient a 
      severity score. These measures were related to the 5HT(2A) T102C and 5HT(2C) 
      cys23ser genotype and allele frequencies. RESULTS: Our data supports previous 
      reports of an increased frequency of the C allele and CC genotype of the T102C 
      variant of 5HT(2A) with hallucinations, delusions, psychosis and aberrant motor 
      behaviour, however, we dispute previous associations with depression and 
      aggression. We describe for the first time an increase in the C allele and CC 
      genotype frequencies of the cys23ser variant of 5HT(2C) with anxiety and support 
      previous associations with appetite disturbances in females. CONCLUSION: This 
      review and extension of previous data presents support for the role of 5HT(2A) 
      and 5HT(2C) in the development of certain symptoms, although the effect size may 
      be small.
FAU - Pritchard, Antonia L
AU  - Pritchard AL
AD  - Department of Human Genetics, G Floor CBCRC Building, Queensland Institute of 
      Medical Research, 300 Herston Road, Herston, Brisbane 4006, Australia. 
      Antonia.Pritchard@qimr.edu.au
FAU - Harris, Judith
AU  - Harris J
FAU - Pritchard, Colin W
AU  - Pritchard CW
FAU - Coates, John
AU  - Coates J
FAU - Haque, Sayeed
AU  - Haque S
FAU - Holder, Roger
AU  - Holder R
FAU - Bentham, Peter
AU  - Bentham P
FAU - Lendon, Corinne L
AU  - Lendon CL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061113
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
RN  - 0 (Receptor, Serotonin, 5-HT2A)
RN  - 0 (Receptor, Serotonin, 5-HT2C)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/complications
MH  - Behavioral Symptoms/etiology/*genetics
MH  - Cohort Studies
MH  - DNA Mutational Analysis
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Neuropsychological Tests
MH  - *Polymorphism, Genetic
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/etiology/*genetics
MH  - Receptor, Serotonin, 5-HT2A/*genetics
MH  - Receptor, Serotonin, 5-HT2C/*genetics
EDAT- 2006/11/14 09:00
MHDA- 2008/03/28 09:00
CRDT- 2006/11/14 09:00
PHST- 2006/03/17 00:00 [received]
PHST- 2006/09/28 00:00 [revised]
PHST- 2006/10/10 00:00 [accepted]
PHST- 2006/11/14 09:00 [pubmed]
PHST- 2008/03/28 09:00 [medline]
PHST- 2006/11/14 09:00 [entrez]
AID - S0197-4580(06)00388-5 [pii]
AID - 10.1016/j.neurobiolaging.2006.10.011 [doi]
PST - ppublish
SO  - Neurobiol Aging. 2008 Mar;29(3):341-7. doi: 10.1016/j.neurobiolaging.2006.10.011. 
      Epub 2006 Nov 13.