PMID- 17098367 OWN - NLM STAT- MEDLINE DCOM- 20070319 LR - 20131121 IS - 0306-4530 (Print) IS - 0306-4530 (Linking) VI - 31 IP - 10 DP - 2006 Nov TI - Stress-resistant mice overexpressing glucocorticoid receptors display enhanced BDNF in the amygdala and hippocampus with unchanged NGF and serotonergic function. PG - 1266-77 AB - Dysfunctional glucocorticoid receptor (GR) signaling has been shown to be involved in the pathogenesis of depressive behavior in mice and humans. In accordance with this hypothesis GR overexpressing mice are less susceptible to develop depressive-like behavior when subjected to stressful events. Here, we analyzed GR overexpressing mice for morning and evening content of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and the tissue levels of serotonin and its metabolite 5-hydroxyindoleacetic acid) in brain areas suspected to be involved in stress adaptation. BDNF concentrations in the hippocampus and amygdala/piriform cortex were significantly enhanced in GR overexpressing mice (by maximally +103%) compared to wildtype animals. Diurnal variations, as detected for NGF in the hypothalamus, for BDNF in the frontal cortex and striatum and for serotonergic function in the frontal cortex and hypothalamus, were not affected by the genotype. In conclusion, GR overexpression-dependent increases of hippocampal and amygdala BDNF content presumably represent a dynamic correlate of enhanced stress resistance. FAU - Schulte-Herbruggen, Olaf AU - Schulte-Herbruggen O AD - Department of Psychiatry and Psychotherapy, Charite-University Medicine Berlin, Campus Benjamin Franklin, Eschenallee 3, 14050 Berlin, Germany. FAU - Chourbaji, Sabine AU - Chourbaji S FAU - Ridder, Stephanie AU - Ridder S FAU - Brandwein, Christiane AU - Brandwein C FAU - Gass, Peter AU - Gass P FAU - Hortnagl, Heide AU - Hortnagl H FAU - Hellweg, Rainer AU - Hellweg R LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20061113 PL - England TA - Psychoneuroendocrinology JT - Psychoneuroendocrinology JID - 7612148 RN - 0 (Biogenic Monoamines) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Nerve Growth Factors) RN - 0 (Receptors, Glucocorticoid) RN - 333DO1RDJY (Serotonin) RN - W980KJ009P (Corticosterone) SB - IM MH - Amygdala/*chemistry MH - Animals MH - Biogenic Monoamines/analysis/metabolism MH - Brain Chemistry MH - Brain-Derived Neurotrophic Factor/*analysis MH - Circadian Rhythm MH - Corticosterone/blood MH - Female MH - Hippocampus/*chemistry MH - Male MH - Mice MH - Mice, Inbred C57BL MH - Mice, Transgenic MH - Nerve Growth Factors/*analysis MH - Receptors, Glucocorticoid/*genetics MH - Serotonin/analysis/*physiology MH - Stress, Physiological/*genetics EDAT- 2006/11/14 09:00 MHDA- 2007/03/21 09:00 CRDT- 2006/11/14 09:00 PHST- 2006/03/28 00:00 [received] PHST- 2006/09/19 00:00 [revised] PHST- 2006/09/20 00:00 [accepted] PHST- 2006/11/14 09:00 [pubmed] PHST- 2007/03/21 09:00 [medline] PHST- 2006/11/14 09:00 [entrez] AID - S0306-4530(06)00152-1 [pii] AID - 10.1016/j.psyneuen.2006.09.008 [doi] PST - ppublish SO - Psychoneuroendocrinology. 2006 Nov;31(10):1266-77. doi: 10.1016/j.psyneuen.2006.09.008. Epub 2006 Nov 13.