PMID- 17098478
OWN - NLM
STAT- MEDLINE
DCOM- 20070411
LR  - 20200225
IS  - 1521-6616 (Print)
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Linking)
VI  - 122
IP  - 3
DP  - 2007 Mar
TI  - Coronary artery aneurysms in patients with hyper IgE recurrent infection 
      syndrome.
PG  - 255-8
AB  - Hyper IgE recurrent infection syndrome (HIES, or Job's syndrome) is a primary 
      immunodeficiency characterized by recurrent skin and lung infections, eczema, 
      elevated serum immunoglobulin E (IgE) levels, and various connective tissue and 
      skeletal system abnormalities including characteristic facies, scoliosis, joint 
      hyperextensibility, retained primary dentition, craniosynostosis, osteopenia, and 
      pathologic fractures. We have identified two patients with aneurysmal coronary 
      artery disease. One was a forty-three-year-old man with HIES and coronary artery 
      aneurysms and ectasia identified on cardiac catheterization following myocardial 
      infarction. The other was a 48-year-old man with coronary artery ectasia-aneurysm 
      identified after cardiac catheterization for evaluation of chest pain. Although 
      connective tissue abnormalities are common in HIES, this is the first report of 
      coronary artery aneurysms in HIES. Further studies are necessary to determine the 
      incidence, pathogenesis, and optimal therapy of these arterial abnormalities in 
      HIES.
FAU - Ling, Jennifer C
AU  - Ling JC
AD  - National Institute of Allergy and Infectious Diseases, National Institutes of 
      Health, Bethesda, MD 20892, USA.
FAU - Freeman, Alexandra F
AU  - Freeman AF
FAU - Gharib, Ahmed M
AU  - Gharib AM
FAU - Arai, Andrew E
AU  - Arai AE
FAU - Lederman, Robert J
AU  - Lederman RJ
FAU - Rosing, Douglas R
AU  - Rosing DR
FAU - Holland, Steven M
AU  - Holland SM
LA  - eng
GR  - Z01 HL005062-05/Intramural NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20061113
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Coronary Aneurysm/*complications/diagnosis/immunology
MH  - Diagnosis, Differential
MH  - Humans
MH  - Hypergammaglobulinemia/*complications/diagnosis/immunology
MH  - Immunoglobulin E/*blood
MH  - Job Syndrome/*complications/diagnosis/immunology
MH  - Male
MH  - Middle Aged
PMC - PMC6588833
MID - NIHMS18639
EDAT- 2006/11/14 09:00
MHDA- 2007/04/12 09:00
PMCR- 2019/06/22
CRDT- 2006/11/14 09:00
PHST- 2006/08/03 00:00 [received]
PHST- 2006/09/22 00:00 [revised]
PHST- 2006/10/08 00:00 [accepted]
PHST- 2006/11/14 09:00 [pubmed]
PHST- 2007/04/12 09:00 [medline]
PHST- 2006/11/14 09:00 [entrez]
PHST- 2019/06/22 00:00 [pmc-release]
AID - S1521-6616(06)00911-9 [pii]
AID - 10.1016/j.clim.2006.10.005 [doi]
PST - ppublish
SO  - Clin Immunol. 2007 Mar;122(3):255-8. doi: 10.1016/j.clim.2006.10.005. Epub 2006 
      Nov 13.