PMID- 17100626
OWN - NLM
STAT- MEDLINE
DCOM- 20070116
LR  - 20220224
IS  - 1873-4286 (Electronic)
IS  - 1381-6128 (Linking)
VI  - 12
IP  - 32
DP  - 2006
TI  - Toll-like receptor signaling mechanisms involved in dendritic cell activation: 
      potential therapeutic control of T cell polarization.
PG  - 4247-54
AB  - Dendritic cells (DCs) represent a bridge between innate and adaptive immunity, 
      being the maturation process dependent on the binding of pathogen-associated 
      molecular patterns (PAMPs) to Toll-Like Receptors (TLRs) expressed on their 
      surface. TLRs associated to adaptor proteins, following binding to PAMPs, are 
      able to skew specific immune responses towards the T helper (h)(1)- or the 
      Th(2)-type according to the antigenic stimulation involved. Of note, other 
      receptors different from TLRs are expressed on DCs which are also able to 
      recognize PAMPs. Among them, one should mention the DC-specific ICAM-3-grabbing 
      nonintegrin, the mannose receptor, Dectin-1 (the major beta-glucan receptor) and 
      NOD2. Finally, the possibility to interfere therapeutically with the 
      TLR-dependent and -independent signaling pathways in DCs is reviewed. According 
      to current literature, DC activation, their antigen uptake capacity and migration 
      can be enhanced with different experimental procedures whose use in humans is 
      still under evaluation. However, just recently a probiotic cocktail VSL3, 
      successfully used in patients with pouchitis, seems to act on DCs, promoting 
      abundant release of Interleukin-10 in the gut. These novel therapeutic strategies 
      based on the modulation of the signaling pathways in DCs seem to be encouraging 
      for the treatment of inflammatory and autoimmune diseases.
FAU - Amati, Luigi
AU  - Amati L
AD  - National Institute for Digestive Diseases, Castellana Grotte, Bari, Italy.
FAU - Pepe, Maria
AU  - Pepe M
FAU - Passeri, Maria Elena
AU  - Passeri ME
FAU - Mastronardi, Maria Letizia
AU  - Mastronardi ML
FAU - Jirillo, Emilio
AU  - Jirillo E
FAU - Covelli, Vito
AU  - Covelli V
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Pharm Des
JT  - Current pharmaceutical design
JID - 9602487
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - *Signal Transduction
MH  - Th1 Cells/cytology/*immunology
MH  - Th2 Cells/cytology/*immunology
MH  - Toll-Like Receptors/*immunology/metabolism
RF  - 104
EDAT- 2006/11/15 09:00
MHDA- 2007/01/17 09:00
CRDT- 2006/11/15 09:00
PHST- 2006/11/15 09:00 [pubmed]
PHST- 2007/01/17 09:00 [medline]
PHST- 2006/11/15 09:00 [entrez]
AID - 10.2174/138161206778743583 [doi]
PST - ppublish
SO  - Curr Pharm Des. 2006;12(32):4247-54. doi: 10.2174/138161206778743583.