PMID- 17100736
OWN - NLM
STAT- MEDLINE
DCOM- 20070215
LR  - 20200728
IS  - 0905-4383 (Print)
IS  - 1600-0781 (Electronic)
IS  - 0905-4383 (Linking)
VI  - 22
IP  - 6
DP  - 2006 Dec
TI  - Failure of physiologic doses of pure UVA or UVB to induce lesions in 
      photosensitive cutaneous lupus erythematosus: implications for phototesting.
PG  - 290-6
AB  - BACKGROUND: Phototesting studies in cutaneous lupus erythematosus have yielded 
      variable results, with most trials reporting photo-induction of lesions by both 
      UVA and UVB in substantial numbers of patients. OBJECTIVES: To determine the 
      minimal erythema dose in patients with subacute cutaneous lupus erythematosus 
      (SCLE) and controls. PATIENTS/METHODS: We phototested nine patients with SCLE and 
      14 skin type-matched controls, using repetitive dosing of UVA1 and UVB, but with 
      filters that removed most of the shorter UVC and longer infrared and visible 
      light. In addition, DNA was isolated from anticoagulated blood to genotype the 
      TNF-alpha 308 region in each patient and control. RESULTS: We were unable to 
      demonstrate a difference in minimal erythema dose (MED) between patients and 
      controls, or any correlation of MED with either TNF genotype or systemic drug 
      therapy for SCLE. In addition, no SCLE skin lesions were induced in the nine 
      patients with either UVA or UVB, and one patient cleared a skin lesion after 
      low-dose UVA1 irradiation. CONCLUSIONS: The potential role of wavelengths outside 
      the UVA and UVB range in the photo-induction of cutaneous lupus skin lesions 
      needs to be investigated, and there is a need to standardize phototesting 
      equipment and procedures for patients with cutaneous lupus erythematous.
FAU - Lokitz, Michele L
AU  - Lokitz ML
AD  - The University of Pennsylvania, Philadelphia, PA, USA.
FAU - Billet, Sara
AU  - Billet S
FAU - Patel, Purvisha
AU  - Patel P
FAU - Kwon, Eun Ji
AU  - Kwon EJ
FAU - Sayre, Robert M
AU  - Sayre RM
FAU - Sullivan, Kathleen E
AU  - Sullivan KE
FAU - Werth, Victoria P
AU  - Werth VP
LA  - eng
GR  - K24 AR002207/AR/NIAMS NIH HHS/United States
GR  - 1K24AR002207/AR/NIAMS NIH HHS/United States
GR  - K24-AR 02207/AR/NIAMS NIH HHS/United States
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Photodermatol Photoimmunol Photomed
JT  - Photodermatology, photoimmunology & photomedicine
JID - 9013641
SB  - IM
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Lupus Erythematosus, Cutaneous/*diagnosis/pathology
MH  - Male
MH  - Photosensitivity Disorders/*diagnosis/pathology
MH  - Predictive Value of Tests
MH  - Radiation Dosage
MH  - Skin Physiological Phenomena/radiation effects
MH  - Skin Tests/*standards
MH  - *Ultraviolet Rays
PMC - PMC7382894
MID - NIHMS474864
EDAT- 2006/11/15 09:00
MHDA- 2007/02/16 09:00
PMCR- 2020/07/26
CRDT- 2006/11/15 09:00
PHST- 2006/11/15 09:00 [pubmed]
PHST- 2007/02/16 09:00 [medline]
PHST- 2006/11/15 09:00 [entrez]
PHST- 2020/07/26 00:00 [pmc-release]
AID - PPP255 [pii]
AID - 10.1111/j.1600-0781.2006.00255.x [doi]
PST - ppublish
SO  - Photodermatol Photoimmunol Photomed. 2006 Dec;22(6):290-6. doi: 
      10.1111/j.1600-0781.2006.00255.x.