PMID- 17101294
OWN - NLM
STAT- MEDLINE
DCOM- 20070307
LR  - 20220311
IS  - 1521-6616 (Print)
IS  - 1521-6616 (Linking)
VI  - 122
IP  - 2
DP  - 2007 Feb
TI  - Peripheral blood dendritic cells and monocytes are differently regulated in the 
      elderly.
PG  - 220-8
AB  - Dendritic cells (DCs) are the single most central player in all immune responses. 
      To assess whether DC alterations may contribute to the immune dysregulation that 
      affects the elderly, we investigated the effects of ageing on DCs. We analyzed 
      the number, phenotype and function of peripheral blood DCs from 70 healthy 
      subjects aged 20-92 years by using flow cytometric methods that allow cell 
      characterization directly in whole blood samples. We demonstrated that the number 
      of myeloid DCs progressively declines with age. This finding was accompanied by a 
      decrease of CD34+ precursors and increase of circulating monocytes, suggesting 
      that the entire differentiation process of antigen presenting cells is partially 
      dysregulated in the elderly. DCs from aged individuals also appeared to have a 
      more mature phenotype and impaired ability to produce IL-12 upon stimulation. 
      These results may help to clarify the contribution of innate immunity to the 
      development of immunosenescence.
FAU - Della Bella, Silvia
AU  - Della Bella S
AD  - Dipartimento di Scienze e Tecnologie Biomediche, Laboratorio di Immunologia, 
      Universita degli Studi di Milano, Milano, Italy. silvia.dellabella@unimi.it 
      <silvia.dellabella@unimi.it>
FAU - Bierti, Luigi
AU  - Bierti L
FAU - Presicce, Pietro
AU  - Presicce P
FAU - Arienti, Rossana
AU  - Arienti R
FAU - Valenti, Marta
AU  - Valenti M
FAU - Saresella, Marina
AU  - Saresella M
FAU - Vergani, Carlo
AU  - Vergani C
FAU - Villa, Maria L
AU  - Villa ML
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061113
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (Antigens, CD34)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/blood/*immunology
MH  - Antigens, CD34/biosynthesis/blood/metabolism
MH  - Blood Cell Count
MH  - Dendritic Cells/*immunology/metabolism
MH  - Female
MH  - Humans
MH  - Immunophenotyping
MH  - Male
MH  - Middle Aged
MH  - Monocytes/*immunology/metabolism
MH  - Stem Cells/immunology/metabolism
EDAT- 2006/11/15 09:00
MHDA- 2007/03/08 09:00
CRDT- 2006/11/15 09:00
PHST- 2006/06/21 00:00 [received]
PHST- 2006/09/14 00:00 [revised]
PHST- 2006/09/24 00:00 [accepted]
PHST- 2006/11/15 09:00 [pubmed]
PHST- 2007/03/08 09:00 [medline]
PHST- 2006/11/15 09:00 [entrez]
AID - S1521-6616(06)00902-8 [pii]
AID - 10.1016/j.clim.2006.09.012 [doi]
PST - ppublish
SO  - Clin Immunol. 2007 Feb;122(2):220-8. doi: 10.1016/j.clim.2006.09.012. Epub 2006 
      Nov 13.