PMID- 1710174
OWN - NLM
STAT- MEDLINE
DCOM- 19910705
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 65
IP  - 5
DP  - 1991 May 31
TI  - trkB encodes a functional receptor for brain-derived neurotrophic factor and 
      neurotrophin-3 but not nerve growth factor.
PG  - 885-93
AB  - A variety of findings seem to functionally link brain-derived neurotrophic factor 
      (BDNF) and neurotrophin-3 (NT-3), while distinguishing both of these factors from 
      the third member of the neurotrophin family, nerve growth factor (NGF). Here we 
      demonstrate that all three of these neuronal survival molecules bind similarly to 
      the low affinity NGF receptor, but that BDNF and NT-3, unlike NGF, do not act via 
      the high affinity NGF receptor. However, both BDNF and NT-3, but not NGF, bind to 
      full-length and truncated forms of a receptor-like tyrosine kinase, trkB, for 
      which no ligand had previously been identified. In addition to binding BDNF and 
      NT-3, trkB can mediate functional responses to both of these neurotrophins when 
      it is expressed in PC12 cells, although BDNF appears to be the more effective 
      ligand. Thus trkB encodes an essential component of a functional receptor for 
      BDNF and NT-3, but not for NGF. Further evidence predicts the existence of 
      additional functional receptors for the neurotrophins.
FAU - Squinto, S P
AU  - Squinto SP
AD  - Regeneron Pharmaceuticals, Inc., Tarrytown, New York 10591.
FAU - Stitt, T N
AU  - Stitt TN
FAU - Aldrich, T H
AU  - Aldrich TH
FAU - Davis, S
AU  - Davis S
FAU - Bianco, S M
AU  - Bianco SM
FAU - Radziejewski, C
AU  - Radziejewski C
FAU - Glass, D J
AU  - Glass DJ
FAU - Masiakowski, P
AU  - Masiakowski P
FAU - Furth, M E
AU  - Furth ME
FAU - Valenzuela, D M
AU  - Valenzuela DM
AU  - et al.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cross-Linking Reagents)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
RN  - 0 (Receptors, Cell Surface)
RN  - 63231-63-0 (RNA)
SB  - IM
GS  - trkB
MH  - Adrenal Gland Neoplasms
MH  - Animals
MH  - Binding, Competitive
MH  - Blotting, Northern
MH  - Brain-Derived Neurotrophic Factor
MH  - Cell Line
MH  - Cross-Linking Reagents
MH  - Kinetics
MH  - Membrane Glycoproteins/*genetics/metabolism
MH  - Nerve Growth Factors/*metabolism/pharmacology
MH  - Nerve Tissue Proteins/*metabolism
MH  - Neurotrophin 3
MH  - Pheochromocytoma
MH  - Protein Binding
MH  - RNA/genetics/isolation & purification
MH  - Rats
MH  - Receptors, Cell Surface/*genetics/metabolism
MH  - Transfection
EDAT- 1991/05/31 00:00
MHDA- 1991/05/31 00:01
CRDT- 1991/05/31 00:00
PHST- 1991/05/31 00:00 [pubmed]
PHST- 1991/05/31 00:01 [medline]
PHST- 1991/05/31 00:00 [entrez]
AID - 0092-8674(91)90395-F [pii]
AID - 10.1016/0092-8674(91)90395-f [doi]
PST - ppublish
SO  - Cell. 1991 May 31;65(5):885-93. doi: 10.1016/0092-8674(91)90395-f.