PMID- 1710187
OWN - NLM
STAT- MEDLINE
DCOM- 19910708
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 192
IP  - 1
DP  - 1991 Jan 3
TI  - The central pressor actions of a novel tachykinin peptide, 
      gamma-preprotachykinin-(72-92)-peptide amide.
PG  - 173-6
AB  - Intracerebroventricular (i.c.v.) injections of a novel tachykinin peptide, 
      gamma-preprotachykinin-(72-92)-peptide amide (neuropeptide gamma, NP gamma), 
      caused dose-dependent increases in blood pressure. The NP gamma-induced pressor 
      responses (1 microgram i.c.v.) were blocked by peripheral administration of 
      pentolinium (10 mg/kg i.v.) and phentolamine (10 mg/kg i.v.), but were not 
      inhibited by a vasopressin antagonist. These results suggest that central NP 
      gamma increases the blood pressure via sympathetic nerve activity.
FAU - Hagio, T
AU  - Hagio T
AD  - Department of Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka 
      University, Japan.
FAU - Takano, Y
AU  - Takano Y
FAU - Nagashima, A
AU  - Nagashima A
FAU - Nakayama, Y
AU  - Nakayama Y
FAU - Tateishi, K
AU  - Tateishi K
FAU - Kamiya, H
AU  - Kamiya H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Peptide Fragments)
RN  - 0 (Tachykinins)
RN  - 114882-65-4 (tachykinin neuropeptide gamma)
RN  - 33507-63-0 (Substance P)
RN  - 86933-74-6 (Neurokinin A)
SB  - IM
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Central Nervous System/*drug effects
MH  - Dose-Response Relationship, Drug
MH  - Heart Rate/drug effects
MH  - Hemodynamics/*drug effects
MH  - Injections, Intraventricular
MH  - Male
MH  - Neurokinin A/pharmacology
MH  - Peptide Fragments/administration & dosage/*pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Substance P/pharmacology
MH  - Tachykinins/administration & dosage/*pharmacology
EDAT- 1991/01/03 00:00
MHDA- 1991/01/03 00:01
CRDT- 1991/01/03 00:00
PHST- 1991/01/03 00:00 [pubmed]
PHST- 1991/01/03 00:01 [medline]
PHST- 1991/01/03 00:00 [entrez]
AID - 0014-2999(91)90086-6 [pii]
AID - 10.1016/0014-2999(91)90086-6 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1991 Jan 3;192(1):173-6. doi: 10.1016/0014-2999(91)90086-6.