PMID- 17105933
OWN - NLM
STAT- MEDLINE
DCOM- 20070110
LR  - 20131121
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1074
DP  - 2006 Aug
TI  - MDMA and seizures: a dangerous liaison?
PG  - 357-64
AB  - In the past decades, there was a massive increase in the abuse of 
      methylenedioxymethamphetamine (MDMA) in the Western countries. Seizure onset 
      after MDMA is considered to be related mainly to its acute systemic effects 
      (e.g., hyponatremia and hyperthermia). However, additional mechanisms might 
      concur to it as well. Experiments aimed at disclosing the basis for such an acute 
      effect have the advantage of profiting of controlled conditions and the "pure" 
      compounds, as opposed to the limits of clinical data which are biased by several 
      confounding factors. Amphetamines exert profound effect on different 
      monoaminergic systems, which might participate to lowering of seizure threshold. 
      Chronic effects of MDMA abuse on seizure threshold have not been explored in 
      detail so far. Recent data showed that in mice receiving small, repeated doses of 
      MDMA, a persisting pro-convulsant effect toward limbic seizures and metabolic 
      hyperexcitability can be observed. In the present article, we reviewed these 
      studies and we report our preliminary experimental data documenting the lack of 
      mossy fiber sprouting at short time intervals following MDMA, when seizure 
      susceptibility is already present.
FAU - Giorgi, Filippo S
AU  - Giorgi FS
AD  - M.D. Department of Human Morphology and Applied Biology, University of Pisa, via 
      Roma 55, 56126 Pisa, Italy.
FAU - Lazzeri, Gloria
AU  - Lazzeri G
FAU - Natale, Gianfranco
AU  - Natale G
FAU - Iudice, Alfonso
AU  - Iudice A
FAU - Ruggieri, Stefano
AU  - Ruggieri S
FAU - Paparelli, Antonio
AU  - Paparelli A
FAU - Murri, Luigi
AU  - Murri L
FAU - Fornai, Francesco
AU  - Fornai F
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - SIV03811UC (Kainic Acid)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Chronic Disease
MH  - Disease Susceptibility
MH  - Drug Interactions
MH  - Hallucinogens/*administration & dosage
MH  - Kainic Acid/pharmacology
MH  - Mice
MH  - Mossy Fibers, Hippocampal/*physiology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage
MH  - Seizures/*chemically induced/physiopathology
RF  - 26
EDAT- 2006/11/16 09:00
MHDA- 2007/01/11 09:00
CRDT- 2006/11/16 09:00
PHST- 2006/11/16 09:00 [pubmed]
PHST- 2007/01/11 09:00 [medline]
PHST- 2006/11/16 09:00 [entrez]
AID - 1074/1/357 [pii]
AID - 10.1196/annals.1369.035 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2006 Aug;1074:357-64. doi: 10.1196/annals.1369.035.