PMID- 17105957
OWN - NLM
STAT- MEDLINE
DCOM- 20070110
LR  - 20131121
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1074
DP  - 2006 Aug
TI  - Prenatal exposure to cocaine and enriched environment: effects on social 
      interactions.
PG  - 620-31
AB  - Exposure to cocaine throughout gestation may produce several deleterious outcomes 
      in the offspring that include effects on neurotransmitter systems and structure 
      of the central nervous system. Such changes are most likely correlated with 
      behavioral alterations. Environmental enrichment (EE) in early stages is a factor 
      that affects structural and behavioral development. This article examines the 
      effects, upon social interactions, of EE during the first month of life in rats 
      prenatally exposed to cocaine. Wistar dams were subcutaneously exposed to 60 
      mg/kg of cocaine divided in two daily doses from gestational day (GD)8 to GD22. 
      Pair-fed controls were given saline vehicle in the same protocol. Offspring were 
      distributed to the different environments in four experimental groups. Group 1: 
      offspring from dams prenatally exposed to cocaine as previously described and 
      reared in EE from postnatal day (PND)1 to PND28; Group 2: pups from 
      cocaine-exposed dams and reared in a standard environment (SE); Group 3: pups 
      from pair-fed saline-exposed dams and reared in EE; Group 4: offspring from 
      saline-exposed dams and reared in SE. On PND21, 24, and 28, rats were examined in 
      several social behavioral categories (play fighting, social investigation, 
      comfort behaviors, and solicitation to play) for 10 min. Animals reared in SE do 
      not display any differences due to treatment in the behavioral categories 
      analyzed. Control offspring reared in EE presented decreased play fighting, 
      decreased solicitation to play, and decreased social investigation compared to 
      the control SE group, while cocaine-exposed animals reared in EE did not present 
      these variations. These results suggest that EE rearing may unmask hidden effects 
      of prenatal cocaine exposure.
FAU - Magalhaes, Ana
AU  - Magalhaes A
AD  - Neurobehavior Unit, Institute for Molecular and Cellular Biology, University of 
      Porto, Rua do Campo Alegre 823, 4150-180 Porto, Portugal. anam@ibmc.up.pt
FAU - Summavielle, Teresa
AU  - Summavielle T
FAU - Melo, Pedro
AU  - Melo P
FAU - Rosa, Rui
AU  - Rosa R
FAU - Tavares, Maria Amelia
AU  - Tavares MA
FAU - De Sousa, Liliana
AU  - De Sousa L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - I5Y540LHVR (Cocaine)
SB  - IM
MH  - Animals
MH  - *Behavior, Animal
MH  - Cocaine/*toxicity
MH  - Female
MH  - *Interpersonal Relations
MH  - *Maternal Exposure
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/chemically induced
MH  - Rats
MH  - Rats, Wistar
EDAT- 2006/11/16 09:00
MHDA- 2007/01/11 09:00
CRDT- 2006/11/16 09:00
PHST- 2006/11/16 09:00 [pubmed]
PHST- 2007/01/11 09:00 [medline]
PHST- 2006/11/16 09:00 [entrez]
AID - 1074/1/620 [pii]
AID - 10.1196/annals.1369.060 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2006 Aug;1074:620-31. doi: 10.1196/annals.1369.060.