PMID- 17105959
OWN - NLM
STAT- MEDLINE
DCOM- 20070110
LR  - 20131121
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 1074
DP  - 2006 Aug
TI  - MDMA in adolescent male rats: decreased serotonin in the amygdala and behavioral 
      effects in the elevated plus-maze test.
PG  - 643-9
AB  - Long-term behavioral consequences of the neurotoxicity produced by 
      3,4-methylenedioxymethamphetamine (MDMA) in the adolescent rat are still mostly 
      unknown. Here, adolescent male rats (postnatal day 45 PND [45]) were exposed to 
      10 mg/kg of MDMA, intraperitoneally, every 2 h for 6 h. Controls were given 0.9% 
      saline in the same protocol. Ten days after exposure, the behavioral effects of 
      MDMA were assessed in the elevated plus-maze (n = 6 per group). After behavioral 
      testing, animals were sacrificed and the amygdalae were dissected and processed 
      for HPLC determination of dopamine (DA), serotonin (5-HT), and metabolites. 
      Results showed a significant decrease in the 5-HT content (P < 0.05), but no 
      significant alterations in DA or its metabolites. Behavioral observation in the 
      elevated plus-maze showed a decreased number of entries in the unprotected arms 
      (P < 0.05), which were correlated to the number of entries and time spent in the 
      central platform. Rearing was also decreased (P < 0.05). No differences were 
      observed in head dips, grooming, or number of entries in the protected arms of 
      the apparatus. Therefore, we conclude that, as in the adult rat, exposure to MDMA 
      in the adolescent rat is associated to long-term depletion of the 5-HT content 
      and increased anxiety-like behavior.
FAU - Faria, Raquel
AU  - Faria R
AD  - IBMC - Neurobehavior Unit, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal.
FAU - Magalhaes, Ana
AU  - Magalhaes A
FAU - Monteiro, Pedro R R
AU  - Monteiro PR
FAU - Gomes-Da-Silva, Joana
AU  - Gomes-Da-Silva J
FAU - Amelia Tavares, Maria
AU  - Amelia Tavares M
FAU - Summavielle, Teresa
AU  - Summavielle T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 333DO1RDJY (Serotonin)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Amygdala/drug effects/*metabolism
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Male
MH  - Maze Learning
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Serotonin/*metabolism
EDAT- 2006/11/16 09:00
MHDA- 2007/01/11 09:00
CRDT- 2006/11/16 09:00
PHST- 2006/11/16 09:00 [pubmed]
PHST- 2007/01/11 09:00 [medline]
PHST- 2006/11/16 09:00 [entrez]
AID - 1074/1/643 [pii]
AID - 10.1196/annals.1369.062 [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2006 Aug;1074:643-9. doi: 10.1196/annals.1369.062.