PMID- 17106278
OWN - NLM
STAT- MEDLINE
DCOM- 20070319
LR  - 20200930
IS  - 1525-4135 (Print)
IS  - 1525-4135 (Linking)
VI  - 44
IP  - 2
DP  - 2007 Feb 1
TI  - Human leukocyte antigen class I and class II allele frequencies and HIV-1 
      infection associations in a Chinese cohort.
PG  - 121-31
AB  - China has one of the most rapidly spreading HIV-1 epidemics. To develop a vaccine 
      targeted to specific human leukocyte antigen (HLA) epitopes in this population, 
      allele distribution analysis is needed. We performed low-resolution class I and 
      II HLA typing of a cohort of 393 subjects from mainland China using a polymerase 
      chain reaction with sequence-specific primers (PCR-SSPs). We found 10 class I 
      alleles present in more than 10% of the population: HLA-A*02, HLA-A*11, HLA-A*24, 
      HLA-B*13, HLA-B*15, HLA-B*40, HLA-Cw*03, HLA-Cw*07, HLA-Cw*01, and HLA-Cw*06. 
      Several class II alleles were found at high frequency (>or=10%): HLA-DRB3, 
      HLA-DRB4, HLA-DRB5, HLA-DRB1*0701, HLA-DRB1*1501, HLA-DRB1*0401, HLA-DRB1*0901, 
      HLA-DRB1*1201, HLA-DQB1*0601, HLA-DQB1*0301, HLA-DQB1*0201, HLA-DQB1*0501, and 
      HLA-DQB*0303. We also estimated 2- and 3-locus haplotype frequencies. Because 
      this cohort contained 280 HIV-1-seropositive and 113 HIV-1-seronegative 
      individuals, we compared allele and haplotype frequencies between the infected 
      and control groups to explore correlations between HLA antigens and 
      susceptibility/resistance to HIV infection. The HLA-B*14 allele was only found in 
      the HIV-1-seropositive group, and many 2-locus haplotypes were significantly 
      overrepresented in this group: HLA-B*14/Cw*08, HLA-B*51/Cw*14, HLA-A*02/B*13, 
      HLA-A*31/Cw*14, HLA-A*02/Cw*06, and the class II haplotype 
      HLA-DRB1*1301/DQB1*0601. Alleles significantly increased in the 
      HIV-1-seronegative controls were HLA-B*44, HLA-Cw*04, and HLA-DRB1*1402. 
      Overrepresented 2-locus haplotypes in the control group were HLA-B*44/Cw*04, 
      HLA-A*31/Cw*03, HLA-A*03/Cw*07, HLA-A*11/B*13, HLA-A*11/B*38, HLA-A*24/B*52, and 
      HLA-A*11/Cw*01. The 3-locus haplotypes HLA-A*24/Cw*03/B*40 and 
      HLA-A*02/B*15/DRB1*1201 were found to be increased significantly in the control 
      group. These data contribute to the database of allele frequencies and 
      associations with HIV infection in the Chinese population.
FAU - Li, Shu
AU  - Li S
AD  - Vaccine Laboratory, Nankai University, Tianjin, China.
FAU - Jiao, Hongli
AU  - Jiao H
FAU - Yu, Xu
AU  - Yu X
FAU - Strong, Amie J
AU  - Strong AJ
FAU - Shao, Yiming
AU  - Shao Y
FAU - Sun, Yongtao
AU  - Sun Y
FAU - Altfeld, Marcus
AU  - Altfeld M
FAU - Lu, Yichen
AU  - Lu Y
LA  - eng
GR  - N01-AI-30024/AI/NIAID NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - China
MH  - Cohort Studies
MH  - *Gene Frequency
MH  - Genes, MHC Class I/*genetics
MH  - Genes, MHC Class II/*genetics
MH  - HIV Infections/*genetics/immunology/virology
MH  - HIV-1/*isolation & purification
MH  - HLA Antigens
MH  - Haplotypes
MH  - Histocompatibility Testing
MH  - Humans
MH  - Immunity, Innate/genetics
MH  - Middle Aged
MH  - Statistics as Topic
EDAT- 2006/11/16 09:00
MHDA- 2007/03/21 09:00
CRDT- 2006/11/16 09:00
PHST- 2006/11/16 09:00 [pubmed]
PHST- 2007/03/21 09:00 [medline]
PHST- 2006/11/16 09:00 [entrez]
AID - 10.1097/01.qai.0000248355.40877.2a [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2007 Feb 1;44(2):121-31. doi: 
      10.1097/01.qai.0000248355.40877.2a.