PMID- 1710762
OWN - NLM
STAT- MEDLINE
DCOM- 19910715
LR  - 20190918
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 13
IP  - 1
DP  - 1991 Jan-Feb
TI  - Behavioral and neurochemical effects of prenatal methylenedioxymethamphetamine 
      (MDMA) exposure in rats.
PG  - 13-20
AB  - MDMA is a hallucinogenic drug that is used by the general public as a 
      recreational drug of abuse. The neurobehavioral consequences of prenatal MDMA 
      exposure are unknown. Groups of pregnant rats were gavaged with 0, 2.5, or 10 
      mg/kg MDMA during gestation on alternate gestational days 6-18. Gestational 
      duration, litter size, neonatal birth weights and physical appearance at birth 
      were unaffected by MDMA treatments. Pregnancy weight gain was significantly 
      reduced by MDMA treatment. Progeny growth, maturational parameters (eye opening 
      and incisor eruption times), surface righting reflex, swimming performance, 
      forelimb grip strength, milk-induced behaviors, passive avoidance behavior, 
      figure-8 maze activity over 48 hours, the density of brain serotonin (5-HT) 
      uptake sites, and brain 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) levels were 
      unaffected by MDMA treatments. Olfactory discrimination on postnatal days (PND) 
      9-11 was enhanced in both male and female MDMA-treated progeny, while negative 
      geotaxis (PND 7-10) was delayed in female pups. In contrast to progeny, MDMA 
      caused dose-dependent decreases in 5-HT and 5-HIAA levels in discrete brain areas 
      of the dam. It is concluded that prenatal exposure to MDMA at the levels used 
      here produces only subtle behavioral alterations in developing rats. The dam is 
      more at risk for MDMA-induced 5-HT depletion than is the conceptus.
FAU - St Omer, V E
AU  - St Omer VE
AD  - Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, 
      University of Missouri, Columbia 65211.
FAU - Ali, S F
AU  - Ali SF
FAU - Holson, R R
AU  - Holson RR
FAU - Duhart, H M
AU  - Duhart HM
FAU - Scalzo, F M
AU  - Scalzo FM
FAU - Slikker, W Jr
AU  - Slikker W Jr
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Designer Drugs)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - 54-16-0 (Hydroxyindoleacetic Acid)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/toxicity
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Brain/drug effects/*metabolism
MH  - Designer Drugs/toxicity
MH  - Female
MH  - Hydroxyindoleacetic Acid/metabolism
MH  - Male
MH  - Maternal-Fetal Exchange
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Pregnancy
MH  - Rats
MH  - Serotonin/metabolism
EDAT- 1991/01/11 19:15
MHDA- 2001/03/28 10:01
CRDT- 1991/01/11 19:15
PHST- 1991/01/11 19:15 [pubmed]
PHST- 2001/03/28 10:01 [medline]
PHST- 1991/01/11 19:15 [entrez]
AID - 10.1016/0892-0362(91)90022-o [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 1991 Jan-Feb;13(1):13-20. doi: 
      10.1016/0892-0362(91)90022-o.