PMID- 17109095
OWN - NLM
STAT- MEDLINE
DCOM- 20070213
LR  - 20191210
IS  - 1341-321X (Print)
IS  - 1341-321X (Linking)
VI  - 12
IP  - 5
DP  - 2006 Oct
TI  - Study of nasopharyngeal bacterial flora. Second report. Variations in 
      nasopharyngeal bacterial flora in children aged 6 years or younger when 
      administered antimicrobial agents. Part 2.
PG  - 305-30
AB  - This report focuses on changes in the nasopharyngeal bacterial flora before and 
      after administration of antimicrobial agents in 172 cases of acute upper 
      respiratory infection in patients aged 6 years or younger. The antimicrobial 
      agents administered were amoxicillin (AMPC) (34%), clavulanic acid/amoxicillin 
      compound (11%), cefditren pivoxil (CDTR-PI) (43%), and others (12%). Changes in 
      nasopharyngeal bacterial flora were investigated with reexaminations conducted 
      after 2-5 days (day 2-5 subgroup), 6-10 days (day 6-10 subgroup), and 11 days and 
      thereafter. There was a significant reduction in the Streptococcus pneumoniae 
      detected in the group administered AMPC (AMPC group) in the day 2-5 subgroup and 
      the day 6-10 subgroup. There was also a significant decrease in H. influenzae in 
      the group administered CDTR-PI (CDTR-PI group) in the day 2-5 subgroup. From this 
      it was inferred that for the most part significant changes in infectious 
      nasopharyngeal bacteria occurred in the day 2-5 subgroups. However, a significant 
      improvement in the degree of inflammation, as indicated by leukocyte infiltration 
      images for the AMPC group, was observed in the day 2-5 subgroup, and for the 
      CDTR-PI group in the day 6-10 subgroup. On the other hand, in both the 
      antimicrobial agent groups, S. pneumoniae, Haemophilus influenzae, and Moraxella 
      catarrhalis were newly detected at reexamination. Furthermore, a difference in 
      the incidence of these bacteria was observed between the 2 antimicrobial agent 
      groups. It was suggested that such phenomena related to the survival of resistant 
      strains or a recurrence otitis media.
FAU - Konno, Masatoshi
AU  - Konno M
AD  - Teikyo University School of Medicine, Tokyo, Japan. mrsa@interlink.or.jp
FAU - Baba, Shunkichi
AU  - Baba S
FAU - Mikawa, Haruki
AU  - Mikawa H
FAU - Hara, Kohei
AU  - Hara K
FAU - Matsumoto, Fumio
AU  - Matsumoto F
FAU - Kaga, Kimitaka
AU  - Kaga K
FAU - Nishimura, Tadao
AU  - Nishimura T
FAU - Kobayashi, Toshimitsu
AU  - Kobayashi T
FAU - Furuya, Nobuhiko
AU  - Furuya N
FAU - Moriyama, Hiroshi
AU  - Moriyama H
FAU - Okamoto, Yoshitaka
AU  - Okamoto Y
FAU - Furukawa, Mituru
AU  - Furukawa M
FAU - Yamanaka, Noboru
AU  - Yamanaka N
FAU - Matsushima, Toshiharu
AU  - Matsushima T
FAU - Yoshizawa, Yasuyuki
AU  - Yoshizawa Y
FAU - Kohno, Shigeru
AU  - Kohno S
FAU - Kobayashi, Kunihiko
AU  - Kobayashi K
FAU - Morikawa, Akihiro
AU  - Morikawa A
FAU - Koizumi, Shoichi
AU  - Koizumi S
FAU - Sunakawa, Keisuke
AU  - Sunakawa K
FAU - Inoue, Matsuhisa
AU  - Inoue M
FAU - Ubukata, Kimiko
AU  - Ubukata K
LA  - eng
PT  - Journal Article
DEP - 20061106
PL  - Netherlands
TA  - J Infect Chemother
JT  - Journal of infection and chemotherapy : official journal of the Japan Society of 
      Chemotherapy
JID - 9608375
RN  - 0 (Anti-Infective Agents)
SB  - IM
MH  - Anti-Infective Agents/*therapeutic use
MH  - Child
MH  - Child, Preschool
MH  - Drug Resistance
MH  - Female
MH  - Haemophilus Infections/microbiology
MH  - Haemophilus influenzae/*isolation & purification
MH  - Humans
MH  - Infant
MH  - Male
MH  - Moraxella catarrhalis/*isolation & purification
MH  - Moraxellaceae Infections/microbiology
MH  - Nasopharynx/drug effects/*microbiology
MH  - Otitis Media/drug therapy/microbiology
MH  - Pneumococcal Infections/microbiology
MH  - Polymerase Chain Reaction/methods
MH  - Respiratory Tract Infections/*drug therapy/microbiology
MH  - Streptococcus pneumoniae/*isolation & purification
EDAT- 2006/11/17 09:00
MHDA- 2007/02/14 09:00
CRDT- 2006/11/17 09:00
PHST- 2006/05/15 00:00 [received]
PHST- 2006/07/19 00:00 [accepted]
PHST- 2006/11/17 09:00 [pubmed]
PHST- 2007/02/14 09:00 [medline]
PHST- 2006/11/17 09:00 [entrez]
AID - S1341-321X(06)70915-1 [pii]
AID - 10.1007/s10156-006-0469-4 [doi]
PST - ppublish
SO  - J Infect Chemother. 2006 Oct;12(5):305-30. doi: 10.1007/s10156-006-0469-4. Epub 
      2006 Nov 6.