PMID- 17109894
OWN - NLM
STAT- MEDLINE
DCOM- 20070313
LR  - 20140729
IS  - 0022-510X (Print)
IS  - 0022-510X (Linking)
VI  - 252
IP  - 1
DP  - 2007 Jan 15
TI  - Allelic variation investigation of the estrogen receptor within an Australian 
      multiple sclerosis population.
PG  - 9-12
AB  - Multiple Sclerosis (MS) is a central nervous system (CNS) chronic inflammatory 
      demyelinating disease leading to various neurological disabilities. The disorder 
      is more prevalent for women with a ratio of 3:2 female to male. OBJECTIVES: To 
      investigate variation within the estrogen receptor 1 (ESR1) polymorphism gene in 
      an Australian MS case-control population using two intragenic restriction 
      fragment length polymorphisms; the G594A located in exon 8 detected with the BtgI 
      restriction enzyme and T938C located in intron 1, detected with PvuII. One 
      hundred and ten Australian MS patients were studied, with patients classified 
      clinically as Relapsing Remitting MS (RR-MS), Secondary Progressive MS (SP-MS) or 
      Primary Progressive MS (PP-MS). Also, 110 age, sex and ethnicity matched controls 
      were investigated as a comparative group. No significant difference in the 
      allelic distribution frequency was found between the case and control groups for 
      the ESR1 PvuII (P = 0.50) and Btg1 (P = 0.45) marker. Our results do not support 
      a role for these two ESR1 markers in multiple sclerosis susceptibility, however 
      other markers within ESR1 should not be excluded for potential involvement in the 
      disorder.
FAU - Tajouri, Lotti
AU  - Tajouri L
AD  - Genomics Research Centre, School of Health Science, Griffith University Gold 
      Coast, Southport, Queensland 4215, Australia.
FAU - Fernandez, Francesca
AU  - Fernandez F
FAU - Tajouri, Sophie
AU  - Tajouri S
FAU - Detriche, Geraldine
AU  - Detriche G
FAU - Szvetko, Attila
AU  - Szvetko A
FAU - Colson, Natalie
AU  - Colson N
FAU - Csurhes, Peter
AU  - Csurhes P
FAU - Pender, Michael P
AU  - Pender MP
FAU - Griffiths, Lyn R
AU  - Griffiths LR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061115
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Alleles
MH  - Australia/epidemiology
MH  - Case-Control Studies
MH  - Chi-Square Distribution
MH  - DNA Mutational Analysis
MH  - Estrogen Receptor alpha/*genetics
MH  - Exons
MH  - Female
MH  - Gene Frequency
MH  - Humans
MH  - Introns
MH  - Linkage Disequilibrium
MH  - Male
MH  - Multiple Sclerosis/*genetics
MH  - *Polymorphism, Genetic
EDAT- 2006/11/18 09:00
MHDA- 2007/03/14 09:00
CRDT- 2006/11/18 09:00
PHST- 2006/06/27 00:00 [received]
PHST- 2006/09/20 00:00 [revised]
PHST- 2006/09/22 00:00 [accepted]
PHST- 2006/11/18 09:00 [pubmed]
PHST- 2007/03/14 09:00 [medline]
PHST- 2006/11/18 09:00 [entrez]
AID - S0022-510X(06)00426-6 [pii]
AID - 10.1016/j.jns.2006.09.018 [doi]
PST - ppublish
SO  - J Neurol Sci. 2007 Jan 15;252(1):9-12. doi: 10.1016/j.jns.2006.09.018. Epub 2006 
      Nov 15.