PMID- 17109942
OWN - NLM
STAT- MEDLINE
DCOM- 20070312
LR  - 20131121
IS  - 0091-3057 (Print)
IS  - 0091-3057 (Linking)
VI  - 85
IP  - 3
DP  - 2006 Nov
TI  - The effects of histaminergic agents in the dorsal hippocampus of rats in the 
      elevated plus-maze test of anxiety.
PG  - 500-6
AB  - High levels of histamine are found in the hippocampus. The central histamine 
      system is involved in many physiological behavioural processes including 
      anxiety-related behaviours both in animals and humans. In the present study, we 
      investigated the effects of intra-hippocampal CA1 (intra-CA1) microinjection of 
      histaminergic agents on anxiety-related behaviours in rats, using elevated 
      plus-maze test of anxiety. Intra-CA1 administration of histamine (at the dose of 
      10 microg/rat) increased open arm time (%OAT) and open arm entry (%OAE) but not 
      locomotor activity, thus showing an anxiolytic response. Intra-CA1 microinjection 
      of pyrilamine (H1 receptor antagonist; at the doses of 10, 20 and 40 microg/rat) 
      in combination with histamine (10 microg/rat) showed a decrease in the %OAT and 
      %OAE. Higher dose of the antagonist (40 microg/rat) by itself increased both %OAT 
      and %OAE, but not locomotor activity, indicating an anxiolytic effect. Intra-CA1 
      microinjection of ranitidine (H2 receptor antagonist), at the doses of 10, 20 and 
      40 microg/rat, also reduced the histamine response. Furthermore, the H2 receptor 
      antagonist by itself reduced %OAT and %OAE without affecting locomotor activity. 
      The results may indicate an anxiogenic effect for the antagonist. Our results 
      showed that histamine may modulate anxiety via H1 and H2 receptors in the CA1 
      region of hippocampus of the rat.
FAU - Zarrindast, Mohammad-Reza
AU  - Zarrindast MR
AD  - Department of Pharmacology, School of Medicine and Iranian National Center for 
      Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran. 
      zarinmr@ams.ac.ir
FAU - Torabi, Monirsadat
AU  - Torabi M
FAU - Rostami, Parvin
AU  - Rostami P
FAU - Fazli-Tabaei, Soheila
AU  - Fazli-Tabaei S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20061115
PL  - United States
TA  - Pharmacol Biochem Behav
JT  - Pharmacology, biochemistry, and behavior
JID - 0367050
RN  - 0 (Receptors, Histamine H1)
RN  - 0 (Receptors, Histamine H2)
RN  - 820484N8I3 (Histamine)
RN  - 884KT10YB7 (Ranitidine)
RN  - HPE317O9TL (Pyrilamine)
SB  - IM
MH  - Animals
MH  - Anxiety/chemically induced/*drug therapy
MH  - Hippocampus/*drug effects/physiology
MH  - Histamine/*pharmacology
MH  - Male
MH  - Maze Learning/*drug effects
MH  - Motor Activity/drug effects
MH  - Pyrilamine/pharmacology
MH  - Ranitidine/pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Histamine H1/physiology
MH  - Receptors, Histamine H2/physiology
EDAT- 2006/11/18 09:00
MHDA- 2007/03/14 09:00
CRDT- 2006/11/18 09:00
PHST- 2006/05/21 00:00 [received]
PHST- 2006/09/24 00:00 [revised]
PHST- 2006/09/27 00:00 [accepted]
PHST- 2006/11/18 09:00 [pubmed]
PHST- 2007/03/14 09:00 [medline]
PHST- 2006/11/18 09:00 [entrez]
AID - S0091-3057(06)00321-2 [pii]
AID - 10.1016/j.pbb.2006.09.019 [doi]
PST - ppublish
SO  - Pharmacol Biochem Behav. 2006 Nov;85(3):500-6. doi: 10.1016/j.pbb.2006.09.019. 
      Epub 2006 Nov 15.