PMID- 1711349
OWN - NLM
STAT- MEDLINE
DCOM- 19910801
LR  - 20190819
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 6
IP  - 6
DP  - 1991 Jun
TI  - Role of the neurotrophic factors BDNF and NGF in the commitment of pluripotent 
      neural crest cells.
PG  - 949-55
AB  - Since trophic factors are increasingly recognized as playing a role in some 
      decision-making steps during development, the influence of brain-derived 
      neurotrophic factor (BDNF) and nerve growth factor (NGF) on the commitment of 
      pluripotent neural crest cells was investigated by in vitro clonal analysis. BDNF 
      caused an increase of up to 21-fold in the number of sensory neuron precursors 
      per colony without a corresponding increase in the total number of cells. By 
      contrast, BDNF treatment caused an equivalent decrease in the number of 
      undifferentiated cells per colony. The data suggest that BDNF, but not NGF, 
      directs pluripotent neural crest cells to differentiate along the primary sensory 
      neuron lineage.
FAU - Sieber-Blum, M
AU  - Sieber-Blum M
AD  - Department of Anatomy and Cellular Biology, Medical College of Wisconsin, 
      Milwaukee 53226.
LA  - eng
GR  - HD21423/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Lewis X Antigen)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Nerve Tissue Proteins)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor
MH  - Cell Differentiation/*drug effects
MH  - Cells, Cultured
MH  - Clone Cells
MH  - Embryo, Nonmammalian
MH  - Fluorescent Antibody Technique
MH  - Lewis X Antigen/analysis
MH  - Nerve Growth Factors/*pharmacology
MH  - Nerve Tissue Proteins/*pharmacology
MH  - Neural Crest/*cytology/drug effects
MH  - Neurons, Afferent/*cytology/drug effects
MH  - Quail
MH  - Staining and Labeling
EDAT- 1991/06/01 00:00
MHDA- 1991/06/01 00:01
CRDT- 1991/06/01 00:00
PHST- 1991/06/01 00:00 [pubmed]
PHST- 1991/06/01 00:01 [medline]
PHST- 1991/06/01 00:00 [entrez]
AID - 0896-6273(91)90235-R [pii]
AID - 10.1016/0896-6273(91)90235-r [doi]
PST - ppublish
SO  - Neuron. 1991 Jun;6(6):949-55. doi: 10.1016/0896-6273(91)90235-r.