PMID- 17114017
OWN - NLM
STAT- MEDLINE
DCOM- 20070301
LR  - 20220317
IS  - 1091-255X (Print)
IS  - 1091-255X (Linking)
VI  - 10
IP  - 9
DP  - 2006 Nov
TI  - Prospective trial of laparoscopic nissen fundoplication versus proton pump 
      inhibitor therapy for gastroesophageal reflux disease: Seven-year follow-up.
PG  - 1312-6; discussion 1316-7
AB  - Laparoscopic Nissen fundoplication and proton pump inhibitor (PPI) therapy are 
      both established treatments for gastroesophageal reflux disease (GERD). We have 
      performed a prospective randomized study comparing these two treatments and now 
      have long-term follow-up data. Between July 1997 and August 2001, 183 patients in 
      Norwich took part in a randomized controlled trial comparing laparoscopic Nissen 
      fundoplication and PPI therapy for the treatment of GERD. In October 2005, 
      patients were followed up and asked to complete a reflux symptom questionnaire. 
      Ninety-one patients were randomized to have surgery and 92 to have optimized PPI 
      therapy. After 12 months, those who had been randomized to PPI were offered the 
      opportunity to have surgery. Fifty-four patients went on to have antireflux 
      surgery; the remaining 38 did not. In all three groups, there was a significant 
      improvement in symptom score after the initial 12 months (P < 0.01; Mann-Whitney 
      U test). However, those who later had surgery despite having had optimal PPI 
      treatment beforehand experienced further symptomatic improvement (P < 0.01) at 
      long-term follow-up (median 6.9 years, range, 4.3-8.3). Both optimal PPI therapy 
      and laparoscopic Nissen fundoplication are effective treatments for GERD. 
      However, surgery offers additional benefit for those who have only partial 
      symptomatic relief whilst on PPIs.
FAU - Mehta, Samir
AU  - Mehta S
AD  - Department of Upper Gastrointestinal Surgery, Norfolk and Norwich University 
      Hospital, Colney Lane, Norwich, UK.
FAU - Bennett, John
AU  - Bennett J
FAU - Mahon, David
AU  - Mahon D
FAU - Rhodes, Michael
AU  - Rhodes M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - Netherlands
TA  - J Gastrointest Surg
JT  - Journal of gastrointestinal surgery : official journal of the Society for Surgery 
      of the Alimentary Tract
JID - 9706084
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Anti-Ulcer Agents)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0K5C5T2QPG (Lansoprazole)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/*therapeutic use
MH  - Adult
MH  - Aged
MH  - Anti-Ulcer Agents/*therapeutic use
MH  - Female
MH  - Follow-Up Studies
MH  - *Fundoplication
MH  - Gastroesophageal Reflux/*drug therapy/*surgery
MH  - Humans
MH  - Lansoprazole
MH  - *Laparoscopy
MH  - Male
MH  - Middle Aged
MH  - Omeprazole/*therapeutic use
MH  - Patient Satisfaction
MH  - Prospective Studies
MH  - *Proton Pump Inhibitors
MH  - Severity of Illness Index
MH  - Surveys and Questionnaires
EDAT- 2006/11/23 09:00
MHDA- 2007/03/03 09:00
CRDT- 2006/11/23 09:00
PHST- 2006/06/03 00:00 [received]
PHST- 2006/07/05 00:00 [accepted]
PHST- 2006/11/23 09:00 [pubmed]
PHST- 2007/03/03 09:00 [medline]
PHST- 2006/11/23 09:00 [entrez]
AID - S1091-255X(06)00329-5 [pii]
AID - 10.1016/j.gassur.2006.07.010 [doi]
PST - ppublish
SO  - J Gastrointest Surg. 2006 Nov;10(9):1312-6; discussion 1316-7. doi: 
      10.1016/j.gassur.2006.07.010.