PMID- 17114418
OWN - NLM
STAT- MEDLINE
DCOM- 20070116
LR  - 20190516
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 177
IP  - 11
DP  - 2006 Dec 1
TI  - Cutting Edge: Plasmacytoid dendritic cells provide innate immune protection 
      against mucosal viral infection in situ.
PG  - 7510-4
AB  - Dendritic cells (DCs) are powerful APCs capable of activating naive lymphocytes. 
      Of the DC subfamilies, plasmacytoid DCs (pDCs) are unique in that they secrete 
      high levels of type I IFNs in response to viruses but their role in inducing 
      adaptive immunity remains divisive. In this study, we examined the importance of 
      pDCs and their ability to recognize a virus through TLR9 in immunity against 
      genital HSV-2 infection. We show that a low number of pDCs survey the vaginal 
      mucosa at steady state. Upon infection, pDCs are recruited to the vagina and 
      produce large amounts of type I IFNs in a TLR9-dependent manner and suppress 
      local viral replication. Although pDCs are critical in innate defense against 
      genital herpes challenge, adaptive Th1 immunity developed normally in the absence 
      of pDCs. Thus, by way of migrating directly into the peripheral mucosa, pDCs act 
      strictly as innate antiviral effector cells against mucosal viral infection in 
      situ.
FAU - Lund, Jennifer M
AU  - Lund JM
AD  - Section of Immunobiology, Yale University School of Medicine, New Haven, CT 
      06520, USA.
FAU - Linehan, Melissa M
AU  - Linehan MM
FAU - Iijima, Norifumi
AU  - Iijima N
FAU - Iwasaki, Akiko
AU  - Iwasaki A
LA  - eng
GR  - AI 054359/AI/NIAID NIH HHS/United States
GR  - AI 062428/AI/NIAID NIH HHS/United States
GR  - AI 064705/AI/NIAID NIH HHS/United States
GR  - AI 07019/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Interferon Type I)
RN  - 0 (Tlr9 protein, mouse)
RN  - 0 (Toll-Like Receptor 9)
SB  - IM
MH  - Animals
MH  - Cell Movement/immunology
MH  - Dendritic Cells/cytology/*immunology
MH  - Female
MH  - Herpes Genitalis/*immunology
MH  - Herpesvirus 2, Human/immunology
MH  - *Immunity, Innate
MH  - Immunity, Mucosal
MH  - Interferon Type I/biosynthesis/immunology
MH  - Mice
MH  - Mice, Knockout
MH  - Mucous Membrane/*immunology/virology
MH  - Th1 Cells/immunology
MH  - Toll-Like Receptor 9/immunology/metabolism
MH  - Vagina/*immunology/virology
EDAT- 2006/11/23 09:00
MHDA- 2007/01/17 09:00
CRDT- 2006/11/23 09:00
PHST- 2006/11/23 09:00 [pubmed]
PHST- 2007/01/17 09:00 [medline]
PHST- 2006/11/23 09:00 [entrez]
AID - 177/11/7510 [pii]
AID - 10.4049/jimmunol.177.11.7510 [doi]
PST - ppublish
SO  - J Immunol. 2006 Dec 1;177(11):7510-4. doi: 10.4049/jimmunol.177.11.7510.