PMID- 17114906
OWN - NLM
STAT- MEDLINE
DCOM- 20070208
LR  - 20181201
IS  - 1720-8386 (Electronic)
IS  - 0391-4097 (Linking)
VI  - 29
IP  - 9
DP  - 2006 Oct
TI  - Long-term effects of elevated gastrin levels on calcitonin secretion.
PG  - 771-5
AB  - Gastrin and pentagastrin stimulate thyroid C cells and elevate serum calcitonin 
      levels. Gastrin levels may be elevated when histamine-2 receptor blockers (H2RB) 
      and/or proton pump inhibitors (PPI) are used, or in patients with pernicious 
      anemia (PA). This study was designed to investigate the long-term effects of 
      elevated gastrin levels on serum calcitonin levels. We conducted a pentagastrin 
      stimulation test to evaluate C cell reserves in patients who had been using PPI 
      and/or H2RB for an extended period, as well as in patients with PA. We compared 
      the results with a healthy control group of similar age and sex. A total of 40 
      controls (26 women, 24 men) and 25 patients (15 women, 10 men) using H2RB and/or 
      PPI, and 37 patients (24 women, 13 men) with PA were enrolled. The groups were 
      similar in terms of mean age and sex distribution. Mean fasting gastrin levels, 
      and mean baseline and pentagastrin-stimulated calcitonin levels were 
      significantly higher in the H2RB+PPI and PA groups than in controls. No 
      significant differences were observed between the H2RB+PPI and PA groups. There 
      was no correlation between gastrin and calcitonin levels. However, mean 
      calcitonin levels were significantly higher in subjects with high baseline 
      gastrin levels than in controls. The prevalence of autoimmune thyroid disease was 
      32% in the PA group. Patients with PA and thyroiditis had significantly higher 
      baseline gastrin levels than patients with PA only (p<0.01). PA with autoimmune 
      thyroid disease had also significantly higher baseline and 
      pentagastrin-stimulated calcitonin levels than did PA patients without autoimmune 
      thyroid disease. In conclusion, chronic elevated gastrin levels led to elevated 
      calcitonin levels. Further histopathological studies showing C cell hyperplasia 
      are needed to confirm the mechanism of this relationship.
FAU - Erdogan, M F
AU  - Erdogan MF
AD  - Department of Endocrinology and Metabolic Diseases, Ankara University School of 
      Medicine, Ankara, Turkey.
FAU - Gursoy, A
AU  - Gursoy A
FAU - Kulaksizoglu, M
AU  - Kulaksizoglu M
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - Italy
TA  - J Endocrinol Invest
JT  - Journal of endocrinological investigation
JID - 7806594
RN  - 0 (Gastrins)
RN  - 0 (Histamine Antagonists)
RN  - 0 (Proton Pump Inhibitors)
RN  - 9007-12-9 (Calcitonin)
RN  - EF0NX91490 (Pentagastrin)
SB  - IM
MH  - Adult
MH  - Anemia, Pernicious/blood/etiology
MH  - Calcitonin/blood/*metabolism
MH  - Female
MH  - Gastric Juice/drug effects
MH  - Gastrins/*blood/pharmacology
MH  - Gastritis, Atrophic/blood/complications
MH  - Hematologic Tests/methods
MH  - Histamine Antagonists/therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pentagastrin/pharmacology
MH  - Proton Pump Inhibitors
MH  - Thyroid Gland/cytology/drug effects
MH  - Time
EDAT- 2006/11/23 09:00
MHDA- 2007/02/09 09:00
CRDT- 2006/11/23 09:00
PHST- 2006/11/23 09:00 [pubmed]
PHST- 2007/02/09 09:00 [medline]
PHST- 2006/11/23 09:00 [entrez]
AID - 3037 [pii]
AID - 10.1007/BF03347369 [doi]
PST - ppublish
SO  - J Endocrinol Invest. 2006 Oct;29(9):771-5. doi: 10.1007/BF03347369.